Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE Oligonucleotide sets that probe breakpoints of <i>IGH-BCL2</i> (immunoglobulin heavy-apoptosis regulator) in follicular lymphoma (FL), <i>MYC-IGH</i> (MYC proto-oncogene, bHLH transcription factor-immunoglobulin heavy) in Burkitt lymphoma (BL) and <i>BCR-ABL1</i> (RhoGEF and GTPase activating protein-ABL proto-oncogene 1, non-receptor tyrosine kinase) in chronic myelogenous leukemia (CML) were designed. 28515100 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE MYC-R lymphomas show poor outcomes even when treated with intensive immunochemotherapy for BL. 28648593 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE Here we study the effects of BCR ablation on MYC-driven mouse B-cell lymphomas and compare them with observations in human Burkitt lymphoma. 28562582 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE Burkitt lymphoma (BL) is an aggressive B-cell lymphoma characterized by MYC dysregulation. 28619753 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE High-resolution structural and functional genomic analysis of adult Burkitt lymphoma (BL) and high-grade B-cell lymphoma with BL gene signature (adult-molecularly defined BL [mBL]) revealed the MYC-ARF-p53 axis as the primary deregulated pathway. 28801451 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE All BLs carried MYC translocation (P<0.001), whereas LMO2 was only positive in 6/42 (14%) LBCL with MYC translocation (P<0.001). 28288039 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE Hence, shRNA-mediated knock-down of endogenous MYC in human T-ALL and Burkitt's lymphoma cell lines downregulated DNMT3B expression. 29100357 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE The c-MYC oncogene is overactivated during Burkitt's lymphoma pathogenesis. 28603988 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE All cases showed morphologic and immunophenotypic features of Burkitt lymphoma with MYC rearrangement in all 5 cases tested. 27257042 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE MYC dysregulation needs other cooperating events for BL development. 26887776 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Burkitt lymphoma (BL) is an aggressive B cell lymphoma characterized by the reciprocal translocation of the c-Myc gene with immunoglobulin genes. 27044389 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE This case report documents a 5-year-old female who presented with B-cell lymphoma with lymphoblastic morphology, terminal deoxynucleotidyl transferase expression, MYC rearrangement, and features overlapping with BL. 26785246 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE MYC translocations occurred as single hit (only MYC rearranged, 63%) or multiple hit lymphoma (37%) and presented as acute leukemia (AL) (14%), Burkitt lymphoma (30%), chronic lymphocytic leukemia (CLL) (21%) or other mature B-cell neoplasms (35%). 27810071 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Chromosome 8q24/MYC rearrangement is associated with Burkitt lymphoma and some aggressive B-cell lymphomas, but is rare in chronic lymphocytic leukemia. 26916070 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE MYC heteroclonality was not observed in Burkitt lymphoma and all cases had positive MYC expression. 27125356 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE In vivo studies using a mouse model of Burkitt's Lymphoma provide pre-clinical evidence that these antibiotics can successfully block progression of MYC-dependent tumors. 27590350 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE The correlation of EZH2 expression with aggressive behavior and proliferation rate in B-cell neoplasms suggests that this molecule may function as an oncogenic protein in these neoplasms, with possible regulation by different signaling cascades in different types of aggressive B-cell lymphomas: p-ERK-related signaling in diffuse large B-cell lymphoma, and MYC-related signaling in Burkitt lymphoma and double hit lymphoma. 27282353 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE We identified TP53 mutations in MYC+/BCL2+ lymphomas at a frequency intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma. 24679006 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE BL expressing BCL2 can be considered to be MYC/BCL2 co-expressors, a feature that is associated with poorer outcome in DLBCL but that has not been correlated with outcome in BL so far. 26218299 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE Aggressive B-cell lymphomas including Burkitt lymphoma and DLBCL showed the highest level of MYC protein staining defined as staining in >50% of lymphoma cells. 25581730 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Here we performed whole-genome bisulfite, genome and transcriptome sequencing in 13 IG-MYC translocation-positive Burkitt lymphoma, nine BCL2 translocation-positive follicular lymphoma and four normal germinal center B cell samples. 26437030 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE In addition, both PIM kinases have a reported synergistic effect with c-MYC in mediating tumour development in several cancers, c-MYC gene being translocated to one of the immunoglobulin loci in nearly all BLs. 26643319 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE MYC, a potent oncogene located at chromosome locus 8q24.21, was identified initially by its involvement in Burkitt lymphoma with t(8;14)(q24;q32). 26416427 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE Furthermore, ChIP coupled with detection by quantitative PCR indicated that Myc-5 has the ability to inhibit MYC binding at the target gene promoters and thus cause downregulation at the mRNA level and protein expression of its target genes in human Burkitt's lymphoma model cell line, P493.6, carrying an inducible MYC repression system and the K562 (human chronic myelogenous leukemia) cell line.Single i.v. injection of Myc-5 at 7.5 mg/kg dose caused significant tumor growth inhibition in a MYC-dependent tumor xenograft model without evidence of toxicity. 25611295 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE Molecular analyses support the concept that there is a biological continuum between BL and DLBCL that includes variable activity of MYC, an oncoprotein once thought to be only associated with BL, but now recognized as a major predictor of survival among patients with DLBCL treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). 25468432 2015