Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines. 8402660 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE This work shows that LMP2A can permit tumorigenesis in the presence of an intact p53 pathway, identifying an important contribution of EBV to BL. 19815507 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE To discover regulators of mutp53 protein accumulation, we performed a large-scale RNA interference screen in a Burkitt lymphoma cell line model. 29653964 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Studies in eight Burkitt's lymphoma and lymphoblastoid cell lines (four wild-type p53 and four mutant p53 cell lines) revealed that the DNA-damaging agents assayed tended to exhibit less growth inhibition in the mutant p53 cell lines compared to the wild-type p53 cell lines. 9563901 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Activation of endogenous wt p53 in BLs and lymphoblastoid cell lines led to the induction of SAP and this was inhibited by the specific p53 inhibitor pifithrin-alpha. 15378026 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE We present here genetic data regarding the status of the p53 gene in the Burkitt lymphoma cell line, Raji. 1437144 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE In this study, we have examined the status of MDM2 and p53 in 20 BL cell lines. 9569028 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Further analysis of the BL lines in which p53 had been characterized showed that whereas some lines were essentially resistant to cisplatin, three were rapidly induced to undergo apoptosis. 7588628 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE SIGNIFICANCE: Targeting MDM4 to alleviate degradation of p53 can be exploited therapeutically across Burkitt lymphoma and other cancers with wild-type p53 harboring 1q gain, the most frequent copy number alteration in cancer. 31000522 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE The proportions of tumour cells with accumulation of p53 appeared to correlate with tumour SPF only in EBV DNA positive BLs. 1337333 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE We investigated temporal relationships between ionizing radiation-induced G1 arrest and induction of the p53-regulated genes GADD45, CIP1/WAF1, and MDM2 in a series of Burkitt's lymphoma and lymphoblastoid cell lines that differed in p53 gene status. 7757991 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE We verified that the oncogenic effect of iASPP on Burkitt lymphoma is TAp63 dependent rather than p53 and confirmed that the interaction between CDK1 and iASPP enhanced the inhibitory effect of iASPP on p53 and TAp63. 30105797 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Immunohistochemical overexpression of p53 protein was found in 21% of NHL patients, with the highest incidence of p53 immunoreactivity in cases of Burkitt's lymphoma, follicle center lymphoma grade III, and diffuse large B-cell lymphoma. 12044054 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE TP53 pathway analysis in paediatric Burkitt lymphoma reveals increased MDM4 expression as the only TP53 pathway abnormality detected in a subset of cases. 22845047 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Here we show that chloroquine, a drug that activates the stress-responsive Atm-p53 tumor-suppressor pathway, preferentially enhances the death of Myc oncogene-overexpressing primary mouse B cells and mouse embryonic fibroblasts (MEFs) and impairs Myc-induced lymphomagenesis in a transgenic mouse model of human Burkitt lymphoma. 18097482 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Biological activities of p53 mutants in Burkitt's lymphoma cells. 8492087 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE In this study, immunoglobulin variable (Ig V) region genes, c-myc re-arrangement and sequence and p53 status were analyzed in clones derived from a Burkitt's lymphoma cell line (LAM) in which it was previously demonstrated that Epstein-Barr virus (EBV) infection occurred late during lymphomagenesis. 11072243 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE We also find that the mutational spectrum of p53 in BL differs from that observed in nonlymphoid tumors. 1638540 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 PosttranslationalModification disease BEFREE The role of inactivation of tumor-suppressor loci is best exemplified by the frequent inactivation of p53 in Burkitt's lymphoma and by the recurrent deletion of 6q25-q27 and 6q21-q23 in intermediate- and high-grade non-Hodgkin's lymphoma, respectively. 8218489 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 PosttranslationalModification disease BEFREE Increased rate of transcription contributes to elevated expression of the mutant p53 gene in Burkitt's lymphoma cells. 8603415 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE Combined loss of p53 induction and function due to miRNA-mediated regulation of ATM and NLK, together with the upregulation of TFAP4, may be a central role for human miRNAs in eBL oncogenesis. 29132323 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE We have shown here that in 70% of Burkitt lymphoma cell lines, but not in normal EBV transformed B cell lines, p53 protein is readily detectable by Western blot analysis using either an antibody directed against the 240 epitope or an antibody against wild-type p53. 8344493 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE These results suggest that (i) significant differences in the frequency of p53 mutations are present among subtypes of neoplasms derived from the same tissue; (ii) p53 may play a role in tumor progression in B-cell chronic lymphocytic leukemia; (iii) the presence of both p53 loss/inactivation and c-myc oncogene activation may be important in the pathogenesis of Burkitt lymphoma and its leukemic form L3-type B-cell acute lymphoblastic leukemia. 2052620 1991
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE INZ(c) treatment decreased c-Myc expression at both mRNA and protein level, and suppressed c-Myc transcriptional activity in human Burkitt's lymphoma Raji cells with mutant p53. 25692307 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE Cells from acute lymphoblastic leukemia (ALL) and Burkitt's lymphoma cell lines express elevated levels of p53, while all examined human acute myeloid leukemia cell lines synthesize negligible p53 protein. 2140591 1990