| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Collectively, our findings support the notion that targeting the oncogenic β-catenin by lycorine is a new option to inhibit melanoma cell metastasis, providing a good drug candidate potential for development novel therapeutics against metastatic melanoma. | 30565685 | 2019 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | We describe here a metastatic melanoma with a GOLGA4-RAF1 fusion and pathogenic variants in CTNNB1 and CDKN2A. | 30835257 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | In addition, β-catenin expression is significantly decreased in more aggressive and metastatic melanoma. | 31443765 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Secondary resistance to immunotherapy associated with β-catenin pathway activation or PTEN loss in metastatic melanoma. | 31703593 | 2019 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Emergence of CTNNB1 mutation at acquired resistance to KIT inhibitor in metastatic melanoma. | 28421416 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Sixty-four pre-treatment formalin-fixed and paraffin embedded melanoma samples from MMP treated with a BRAF inhibitor (n = 39) or BRAF and MEK inhibitors (n = 25) were assessed for presence of β-catenin, PD-L1, cluster of differentiation (CD)8, CD103 and forkhead box protein P3 (FOXP3) expression by immunohistochemistry, and results were correlated with clinical outcome. | 28412591 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | These data suggest that beta-catenin is an essential survival factor for metastatic melanoma cells, whereas it is dispensable for the survival of benign melanocytes and primary, non-invasive melanoma cells. | 21858114 | 2011 | ||||
|
0.080 | Biomarker | disease | BEFREE | In our study, 43 primary cutaneous melanoma and 30 metastases were screened for CTNNB1 exon 3 mutations by using a denaturing gradient gel electrophoresis technique and sequencing. beta-Catenin mutations were found in 2 primary melanomas and 1 metastatic melanoma and were not correlated with nuclear accumulation of beta-catenin in these cases. | 11950921 | 2002 |