Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Effective Treatment of Metastatic Melanoma by Combining MAPK and PI3K Signaling Pathway Inhibitors. | 31470659 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Joint action of miR-126 and MAPK/PI3K inhibitors against metastatic melanoma. | 31115969 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Collectively, our results suggest that GA exerts anti-metastasis activity in melanoma cells by suppressing the EMT and angiogenesis through the PI3K/Akt and ERK signaling pathways, and might be used as a phytomedicine against metastatic melanoma. | 31586634 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Aberrant MAPK and PI3K pathway signaling may drive the malignant phenotype in NRAS-mutant and BRAF<sup>WT</sup> NRAS<sup>WT</sup> metastatic melanoma. | 28921907 | 2018 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Intrinsic and acquired resistance of metastatic melanoma to (V600E/K)BRAF and/or MEK inhibitors, which is often caused by activation of the PI3K/AKT survival pathway, represents a major clinical challenge. | 26790143 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma. | 25168062 | 2014 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Novel somatic mutations to PI3K pathway genes in metastatic melanoma. | 22912864 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | ICAM-1 has a critical role in the regulation of metastatic melanoma tumor susceptibility to CTL lysis by interfering with PI3K/AKT pathway. | 19047166 | 2008 |