| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | These data suggest that taking the paradoxical approach of inhibiting rather than activating wild-type p53 may sensitize previously resistant metastatic melanoma cells to therapy. | 31836388 | 2020 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Our findings suggest that TP53 mutation is a potential negative predictor of metastatic melanoma treated with CTLA-4 blockade. | 29793878 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Thus, p53 effectively prevented the conversion of small benign tumors to malignant and metastatic melanoma. p53 activation in cultured primary melanocyte and melanoma cell lines using Nutlin-3, a specific Mdm2 antagonist, supported these findings. | 20849464 | 2010 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Metastatic melanoma is a deadly cancer that fails to respond to conventional chemotherapy and is poorly understood at the molecular level. p53 mutations often occur in aggressive and chemoresistant cancers but are rarely observed in melanoma. | 11196646 | 2001 | ||||
|
0.080 | Biomarker | disease | BEFREE | We have investigated the TP53 status and cell cycle response to ionizing radiation of a series of early passage cell lines (designated NZM1 to NZM15) previously developed from patients with metastatic melanoma. | 11216673 | 2000 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Of the four patients assayed, all developed anti-adenoviral antibodies.Adverse reactions associated with i.t. injection were mild, with no obvious correlation between the incidence, severity, or relationship of the events and drug dose. p53 gene therapy by i.t. injection of a replication-defective adenoviral expression vector is safe, feasible, and biologically effective (with respect to transduction frequency) in patients with either metastatic melanoma or breast cancer. | 10917210 | 2000 | ||||
|
0.080 | Biomarker | disease | BEFREE | Induction of p53 without increase in p21WAF1 in betulinic acid-mediated cell death is preferential for human metastatic melanoma. | 9628583 | 1998 | ||||
|
0.080 | Biomarker | disease | BEFREE | Inhibition of growth and induction of differentiation of metastatic melanoma cells in vitro by genistein: chemosensitivity is regulated by cellular p53. | 9184169 | 1997 |