| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | disease | BEFREE | Suppression of miR-21-3p enhances TRAIL-mediated apoptosis in liver cancer stem cells by suppressing the PI3K/Akt/Bad cascade via regulating PTEN. | 30774424 | 2019 | ||||
|
0.090 | Biomarker | disease | BEFREE | The circulating miR-130b and miR-21 can be used as potential tumor biomarkers to diagnose liver cancer, and the combined detection of serum miR-130b and miR-21 is superior to the diagnosis of HCC. | 31660696 | 2019 | ||||
|
0.090 | Biomarker | disease | BEFREE | Genetic and pharmacologic manipulation of miR-21 does not inhibit the development of liver fibrosis and liver cancer. | 29091291 | 2018 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | We compared the expression of miR-21 targets in 377 patients with liver cancer from the data generated by The Cancer Genome Atlas (TCGA) and found that mRNA levels of 402 miR-21 targets are altered in HCC. | 29538313 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | Both miR-21 and miR-31 expression in HCC tissues did not predict overall survival; however, miR-21 was considered an independent predictor of disease progression together with portal vein thrombosis and higher Barcelona Clinical Liver Cancer stage. | 30191729 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | In this context, the present study investigated the potential of miR-21 as the therapeutic target for the management of liver cancer. | 29807978 | 2018 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | The anti-cancer effects of cisplatin on hepatic cancer are associated with modulation of miRNA-21 and miRNA-122 expression. | 27874954 | 2016 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Liver cancer stem cells (LCSCs) have been shown to express higher levels of microRNA-21 (miR-21). | 27793160 | 2016 | ||||
|
0.090 | Biomarker | disease | BEFREE | This study investigated the regulatory role of Pokemon in Sprouty1 expression and the effect on liver cancer cell growth and proliferation, revealing a novel miR-21-mediated regulatory circuit. | 23355454 | 2013 |