Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 AlteredExpression disease BEFREE In this study, the human liver cancer cell line HepG2 was pre-cultured in different oxygen environments to examine the possible mechanisms of hypoxia-induced doxorubicin resistance. 31420991 2020
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 AlteredExpression disease BEFREE Mechanism study showed that veliparib could significantly enhance the accumulation of doxorubicin in ABCB1-overexpression liver cancer cells, without down-regulating the expression level of ABCB1. 31679697 2020
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 Biomarker disease BEFREE Therefore, the cytotoxic effect of OA was evaluated on human breast cancer MDA-MB-231 and human liver cancer HepG2 with absence and presence of P-gp, respectively. 31704064 2020
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 Biomarker disease BEFREE Hence, co-treatment with an ABCB1 inhibitor and an anticancer agent may be effective for the treatment of patients with liver cancer containing the C-terminal truncated HBx.[BMB Reports 2019; 52(5): 330-335]. 30982500 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 AlteredExpression disease BEFREE Conversely, MDR1 was negatively correlated with E‑cadherin expression in liver cancer samples. 30066890 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 AlteredExpression disease BEFREE These findings suggest that the knockdown of NANOG in HepG2 human cells resulted in decreased MDR1 expression and increased doxorubicin sensitivity, and NANOG could be used as a novel potential therapeutic target to reverse multidrug resistance of liver cancer. 24647772 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 AlteredExpression disease BEFREE Multidrug resistance (MDR) has become a major impediment to a successful treatment for liver cancer patients, and one of the common reasons for MDR is the activation of ABCB1 gene, leading to the over-expression of P-glycoprotein (P-gp), which conferred cancer cells be resistant to a broad range of anticancer drugs. 23925649 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 Biomarker disease BEFREE To explore whether P-glycoprotein (Pgp) and other pumps, multidrug resistance-associated protein (MRP) and lung resistance protein (LRP), could affect tumor accumulation and efflux of 99mTc-MIBI in liver cancer. 15112342 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 AlteredExpression disease BEFREE Resistance to cancer chemotherapy in primary liver carcinoma results from P-glycoprotein protein expression. 7904895 1994