| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | Our findings are the first to provide compelling evidence of the role of BRCA2 in ESCC genetic susceptibility in Chinese, suggesting defective homologous recombination is an underlying cause in ESCC pathogenesis, which is amenable to therapeutic options based on synthetic lethality approaches such as targeting BRCA2 with PARP1 inhibitors in ESCC. | 31396961 | 2020 | ||||
|
0.070 | Biomarker | disease | BEFREE | Xanthohumol also decreased expression of cyclin D1 and increased the levels of cleaved caspase-3, -7 and -PARP as well as Bax, Bim<sub>s</sub> and cytochrome c in ESCC cells by downregulating AKT signaling targets, including glycogen synthase kinase 3 beta (GSK3β), mammalian target of rapamycin, and ribosomal protein S6 (S6K). | 30887517 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | These findings have profound potential implications for the use of cell cycle inhibitors in EAC and PARP inhibitors in ESCC, which may provide novel mechanistic insights into the plasticity of esophageal cancer. | 31002369 | 2019 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | The present study suggests that PARP1 expression has a critical role in ESCC progression, and may be a clinical therapeutic target. | 28789382 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | Our data demonstrate that YM155 did not trigger apoptosis, but induced parthanatos, a cell death dependent on PARP-1 hyper-activation, and support clinical development of YM155 in ESCC. | 26090615 | 2015 | ||||
|
0.070 | Biomarker | disease | BEFREE | Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines. | 24219164 | 2014 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | In the final model, 4 SNPs, including 2 in the coding regions (ADPRT Val762Ala and MBD4 Glu346Lys) and others in noncoding regions (LIG3 A3704G and XRCC1 T-77C), remained as significant predictors for the risk of ESCC. | 15205355 | 2004 |