Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE In conclusion, our study first reported that PTP1B was the positive regulator of EGFR by dephosphorylating MYH9 at Y1408 to promote cell migration and invasion, which revealed the regulatory mechanism of PTP1B-MYH9-EGFR axis in ESCC. 31735331 2020
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE Single Nucleotide Polymorphisms in MicroRNA-Binding Site of Epidermal Growth Factor Receptor Signaling Pathway and Susceptibility to Esophageal Squamous Cell Carcinoma. 31269493 2020
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE The effect of anti-epidermal growth factor receptor targeted treatment in esophageal squamous cell carcinoma (ESCC) is still unclear. 31031851 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE However, the specific effects of miR-133b and EGFR on ESCC remain unclear. 30594787 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE <i>Conclusion:</i> Our results establish the functional role of RNF128 in driving the invasion and metastasis of ESCC through the EGFR/MAPK/MMP-2 pathway, implicating its potential as a candidate therapeutic target and prognostic biomarker for ESCC. 31216681 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE LR004-VC-MMAE showed a potent antitumor effect against ESCC and other EGFR-positive cells with IC<sub>50</sub> values of nM concentrations in vitro. 30372581 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE The results showed that CC genotype of both PLCE1 rs17109671 and EGFR rs2072454 was associated with ESCC prognosis. 31209807 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE ITGB4/FAK/growth factor receptor-bound protein 2 (Grb2), protein kinase B (AKT), and extracellular signal-regulated kinase (ERK) pathways were involved in the regulatory mechanisms of miR-133b/EGFR axis in ESCC metastases in vitro and in vivo. 30479571 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE Overall, our results suggest that an ESCC subtype with EGFR amplification and overexpression benefits from cetuximab treatment, which warrants further clinical confirmation. 30416780 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE EGFR family protein expression was examined by immunohistochemical analysis of tissue microarrays of 94 patients with lymph node-negative ESCC after radical esophagectomy with three-field lymphadenectomy. 29729836 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE The present study investigated the role of miR-1 and its association with phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA) in the pathophysiology of esophageal squamous cell carcinoma (ESCC), and analyzed the effects of miR-1 inhibitor or mimics on sensitivity to epidermal growth factor receptor-tyrosine kinase inhibitors, the alterations of cell cycle distribution and apoptosis in ESCC cells. 29399158 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE Specifically, EGFR and p120-catenin (p120ctn) are commonly dysregulated genes that are indicative of poor prognosis in ESCC. 29541406 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE These data suggests SIRT1 may serve as a predictor of poor prognosis in ESCC, and its mediated tumor-promoting role might be associated with the overexpression of EGFR protein in ESCC. 29625788 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE Taken together, the current study was the first to demonstrate the upregulation of PD-L1 by chemotherapy in ESCC and its regulation through the EGFR/ERK pathway. 30172884 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE This study confirms a direct correlation between MSI1 and EGFR and may support the important role of MSI1 in activation of EGFR through NOTCH/WNT pathways in ESCC. 30202417 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE Both ESCC cell lines and PDXs with EGFR CNG or overexpression are potential candidates for afatinib, and concomitant EGFR/SFKs inhibition could reverse afatinib-acquired resistance caused by SFKs activation in ESCC. 30157900 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE In conclusion, PET imaging biomarkers may be useful for selecting patients that express target molecules and for monitoring therapeutic efficacy of EGFR-targeted therapy in ESCC patients. 30373221 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma. 28059068 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE We identified 11 emerging IHC markers with reproducible results, including eight markers [epidermal growth factor receptor (EGFR), Cyclin D1, vascular endothelial growth factor (VEGF), Survivin, Podoplanin, Fascin, phosphorylated mammalian target of rapamycin (p-mTOR), and pyruvate kinase M2 (PKM2)] indicating unfavorable prognosis and 3 markers (P27, P16, and E-cadherin) indicating favorable prognosis of ESCC. 28818096 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE The pre-treatment of ESCC cell strains was carried out using Butaprost (special agonist of PGE2 and EP2) and RNAi of EP2, and we observed the expression of EP2, EGFR, and p-EGFR. 29272001 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE In ESCC cell lines with EGFR high expression, PD-L1 expression was induced significantly when EGFR signaling was activated by radiation and was dramatically inhibited by an EGFR tyrosine kinase inhibitor. 28192623 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE It has been reported that <sup>64</sup> Cu-cetuximab immune-PET represented EGFR expression levels in ESCC tumors and that <sup>177</sup> Lu-cetuximab radioimmunotherapy effectively inhibited the tumor growth. 28777832 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE Functional studies demonstrate that PCLO knockdown remarkably attenuates ESCC malignancy in vitro and in vivo, and ectopic EGFR expression partially compensates for Piccolo loss. 28263981 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE The western blotting results showed that exposure of ESCC cells to resveratrol inhibited EGF-induced EGFR activation in addition to decreasing the total protein levels of EGFR and membrane/nuclear localization. 28123566 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE In this retrospective study, we assessed EGFR overexpression, using immunohistochemistry (IHC) in 68 patients with ESCC, undergoing neoadjuvant chemoradiotherapy and esophagectomy in 2011-2014. 28412829 2017