Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 PosttranslationalModification disease BEFREE Promoter methylation status of MGMT, hMSH2, and hMLH1 and its relationship to corresponding protein expression and TP53 mutations in human esophageal squamous cell carcinoma. 24366688 2014
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 PosttranslationalModification disease BEFREE Promoter methylation of MGMT gene in serum of patients with esophageal squamous cell carcinoma in North East India. 25520135 2014
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease CTD_human Promoter methylation of MGMT gene in serum of patients with esophageal squamous cell carcinoma in North East India. 25520135 2014
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease BEFREE The authors retrospectively analyzed the hypermethylation status of 11 genes using methylation-specific polymerase chain reaction (PCR) and the expression of epidermal growth factor receptor (EGFR), O-6 methylguanine-DNA methyltransferase (MGMT), tumor protein 53 (p53), and transforming growth factor β (TGFβ) using immunohistochemistry in 329 formalin-fixed, paraffin-embedded ESCCs. 23310950 2013
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease BEFREE Our study found the P16, MGMT and hMLH1 demonstrate a high proportion of hypermethylation in esophageal squamous cell cancer cancer tissues, which might be used as biomarkers for cancer detection. 23244153 2012
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease BEFREE Detection of the methylated sequences of hMLH1, hMSH2, and MGMT appears to be promising as a predictive factor in primary ESCC. 21674174 2011
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease BEFREE Increased risk of ESCC metastasis was indicated in MGMT for frequency of presence C allele [Rs7068306: 2.204 (1.244-3.906)], A allele [Rs10734088: 1.968 (1.111-3.484)] and C allele [Rs4751115: 2.178 (1.251-3.791)]. 20128036 2010
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 GeneticVariation disease BEFREE The A allele of the rs7087131 variant of MGMT gene was associated with a decreased risk of ESCC under a dominant model (odds ratio, 0.79; 95% confidence interval, 0.64-0.96; P = 0.02). 19826048 2009
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 GeneticVariation disease BEFREE Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism in esophageal squamous cell carcinoma. 18199718 2008
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease BEFREE The expression levels of four genes (hMSH2, XRCC1, XPD, MGMT) present in PBMC were significantly correlated with increased risk for ESCC, in which there was reduced expression of MGMT, suggesting an important etiology role for MGMT expression in the initiation of ESCC in Huaian of China. 17479411 2007
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 PosttranslationalModification disease BEFREE In the ESCC cell line KYSE 510, treatment with a DNA methyltransferase inhibitor, 2'-deoxy-5-azacytidine partially reversed the CpG hypermethylation status and restored mRNA expression of the MGMT gene. 15703815 2005
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease BEFREE Fifty-one percent (61/119) ESCC showed p53 mutations but the distribution of the mutations did not differ significantly between MGMT-methylated ESCC (44%) and MGMT-unmethylated ESCC (56.2%; P = 0.18). 12807758 2003