| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Association of PIK3CA and MDM2 SNP309 with Cervical Squamous Cell Carcinoma in a Philippine Population. | 31350972 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | The PI3K/AKT/mTOR signaling pathway is frequently activated in HPV-positive cervical squamous cell cancer (CC). | 29103764 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | In summary, DEPTOR is found to promote survival of cervical SCC cells and its reduction induced apoptosis via differential effects on PI3K/AKT and p38 MAPK and can be a potential target in cervical SCC. | 26992219 | 2016 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Somatic mutations and copy number amplification of PIK3CA were associated with response to CCRT in patients with cervical squamous cell carcinoma. | 25773678 | 2015 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | EGFR expression was present in 60/101 (59.4%) CSCCs and was associated with PIK3CA mutation detection (P < 0.05) but not age (P > 0.05). | 26209091 | 2015 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Additional genomic alterations, independent of integration events, include recurrent PIK3CA mutations (and aberrations in other members of the PI3K pathway), alterations in receptor tyrosine kinases (primarily FGFR2 and FGFR3 in HPV-positive HNSCC, and ERBB2 in cervical squamous cell carcinoma), and genes in pathways related to squamous cell differentiation and immune responses. | 25779941 | 2015 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The heterozygous genotype of two loci in the PIK3CA gene (rs3729679: uncorrected P=0.022 and rs12494623: uncorrected P=0.018) was associated with an increased risk of chemoresistance in SCC patients. | 26585822 | 2015 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | In patients with squamous cell carcinoma of the cervix, the presence of PIK3CA mutations was associated with a significantly longer overall survival (median, 9.4 months) than the absence of PIK3CA mutations (median, 4.2 months; p = 0.019). | 25426553 | 2014 |