Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 AlteredExpression disease BEFREE Assessment of the transcriptional activity of p53 improves the prediction of recurrence in superficial transitional cell carcinoma of the bladder. 16000567 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease BEFREE Future analyses of the progress of patients with superficial bladder transitional cell carcinoma and mutated p53 will help clarify this aspect. 15539839 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker disease BEFREE In the present study we correlate the p53 gene mutations in tumour tissue with urine sediment using a functional assay in yeast, and relate the p53 status to the outcome in a group of patients with transitional cell carcinoma of the bladder. 15308588 2004
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.200 AlteredExpression disease BEFREE HER-2/neu protein overexpression and gene amplification in human transitional cell carcinoma of the bladder. 15072912 2004
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.200 Biomarker disease BEFREE HER2/neu gene amplification and protein overexpression in G3 pT2 transitional cell carcinoma of the bladder: a role for anti-HER2 therapy? 14687790 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker disease BEFREE We outline the basic constitutive functions of p53 and summarize its current role in the management of transitional cell carcinoma of the bladder. 12629332 2003
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.200 AlteredExpression disease BEFREE HER2/neu overexpression in the development of muscle-invasive transitional cell carcinoma of the bladder. 14520464 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease BEFREE The expression pattern of PAX5 in the tissue of superficial bladder transitional cell carcinoma (TCC), its prognostic value and its correlation with p53 immunohistochemistry and p53 mutation analysis were evaluated. 14577491 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker disease BEFREE To determine prognostic factors for survival in bladder transitional cell carcinoma (TCC), and the prognostic value of p53 and ki67. 12074407 2002
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.200 AlteredExpression disease BEFREE As C-erbB-2 oncoprotein and vascular endothelial growth factor (VEGF) have been shown to be over-expressed in TCC of the bladder, it has been postulated that they may be important in its pathogenesis.The purpose of this study was to 1.) differentially evaluate the effect of BCG immunotherapy in treated and untreated cohorts on the immunohistochemical expression of C-erbB-2 and VEGF in formalin-fixed paraffin-embedded sections of superficial and superficially invasive (Stage Ta-T1) transitional cell carcinoma of the bladder. 12474525 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease BEFREE Overexpression of c-met as a prognostic indicator for transitional cell carcinoma of the urinary bladder: a comparison with p53 nuclear accumulation. 11896103 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker disease BEFREE We conclude that, in contrast to immunohistochemical accumulation, gene alterations play only a minor role in tumor recurrence of p53 in patients with superficial transitional cell carcinoma of the bladder, and that immunohistochemical accumulation of the p53 protein has to be explained by mechanisms other than gene mutations. 11223675 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker disease BEFREE In addition to immunohistochemical and single strand conformational polymorphism analysis, we performed 3-D p53 protein modeling and correlated our results with the disease-free survival of patients with muscle invasive transitional cell carcinoma of the bladder who underwent surgery. 11696726 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker disease BEFREE Role of TP53 in repair of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human transitional cell carcinoma of the urinary bladder. 11159753 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease BEFREE The relation of mutant p53 accumulation in transitional cell carcinoma of bladder with pathological stage, grade, recurrence and survival. 12230275 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker disease BEFREE Eighty-seven transitional cell carcinoma of the bladder were analyzed by immunohistochemistry (IHC) for p53 nuclear accumulation, and the results compared to mutations detected in the p53 gene evaluated by polymerase chain reaction single-strand conformation polymorphism (SSCP) and DNA sequence analysis. 10675477 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 AlteredExpression disease BEFREE We analyzed the relationship between p53 protein expression in bladder cancer tissue, p53 autoantibodies in serum and the clinical course of 32 patients with and 10 patients without transitional cell carcinoma of the urinary bladder. 10782026 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease BEFREE We assess the prognostic significance of bcl-2 expression, p53 mutation and ki-67 index for low grade, superficial transitional cell bladder carcinoma. 10687971 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 AlteredExpression disease BEFREE DNA ploidy and p53 protein expression in superficial transitional cell carcinoma of the bladder. 10772009 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 AlteredExpression disease BEFREE Evaluation of P53 protein overexpression, Ki67 proliferative activity and mitotic index as markers of tumour recurrence in superficial transitional cell carcinoma of the bladder. 10940702 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease BEFREE Progression in transitional cell carcinoma of the urinary bladder--analysis of Tp53 gene mutations by temperature gradients and sequence in tumor tissues and in cellular urine sediments. 10757120 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease BEFREE The best documented factors involved in urinary bladder transitional cell carcinoma (TCC) are ras proto-oncogene activation and p53 suppressor gene mutations. 10079253 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 AlteredExpression disease BEFREE The expression of p53 and bcl-2 in superficial bladder transitional cell carcinoma and its role in the outcome of postoperative intravesical chemotherapy. 9891547 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker disease BEFREE The objective of the present study was to determine whether immunohistochemical staining for p53 was predictive of lymph node metastases in early muscle invasive transitional cell bladder cancer. 10606186 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease BEFREE A bcl-2/bax ratio greater than 1 and p53 gene mutation were closely associated with early relapse in patients with superficial transitional cell carcinoma of the bladder during intravesical chemotherapy after resection. 9817315 1998