Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 238
Gene Symbol: ALK
ALK
0.400 Biomarker disease BEFREE ALK-tRCC is a rare subtype of adult RCC. 31627758 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.400 Biomarker disease BEFREE Our report draws the attention to the possibility that VCL-ALK genotype can be involved in older patients unassociated with sickle cell trait, also expanding the spectrum to ALK-rearranged RCC. 31563285 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.400 GeneticVariation disease BEFREE We include in this review the following new and emerging/provisional renal entities: succinate dehydrogenase-deficient renal cell carcinoma, thyroid-like follicular carcinoma of the kidney, anaplastic lymphoma kinase rearrangement-associated renal cell carcinoma, renal cell carcinomas with prominent smooth muscle stroma, fumarate hydratase-deficient renal cell carcinoma, biphasic squamoid papillary renal cell carcinoma, eosinophilic solid and cystic renal cell carcinoma, atrophic kidney-like renal cell carcinoma, clear cell renal cell carcinoma with giant cells and emperipolesis, Warthin-like papillary renal cell carcinoma, and low-grade oncocytic renal tumour (CD117-negative; cytokeratin 7-positive). 30565301 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.400 GeneticVariation disease BEFREE ALK-TPM3 rearrangement in adult renal cell carcinoma: Report of a new case showing loss of chromosome 3 and literature review. 29405994 2018
Entrez Id: 238
Gene Symbol: ALK
ALK
0.400 Biomarker disease BEFREE A case of anaplastic lymphoma kinase-positive renal cell carcinoma coincident with Hodgkin lymphoma. 29024210 2017
Entrez Id: 238
Gene Symbol: ALK
ALK
0.400 Biomarker disease BEFREE Follow-up data were analyzed for the two cases and eight other ALK-rearranged RCCs reported in the literature. 28199742 2017
Entrez Id: 238
Gene Symbol: ALK
ALK
0.400 GeneticVariation disease BEFREE There are only rare reports of RCC with an ALK-TMP3 fusion, and these tumours can express TFE3 on some unknown basis not related to a TFE3 translocation. 27450657 2016
Entrez Id: 238
Gene Symbol: ALK
ALK
0.400 Biomarker disease BEFREE To date, less than 17 cases of RCCs with ALK rearrangements are reported in children and adults. 27554841 2016
Entrez Id: 238
Gene Symbol: ALK
ALK
0.400 GeneticVariation disease BEFREE The currently recognized 2016 World Health Organization classification for RCC subtypes is briefly discussed, including new diagnostic entities (clear cell papillary RCC, hereditary leiomyomatosis and RCC-associated RCC, succinate dehydrogenase-deficient RCC, tubulocystic RCC, and acquired cystic disease-associated RCC) and areas of evolving RCC classification, such as transcription elongation factor B subunit 1 (TCEB1)-mutated RCC/RCC with angioleiomyoma-like stroma/RCC with leiomyomatous stroma, RCC associated with anaplastic lymphoma receptor tyrosine kinase (ALK) gene rearrangement, thyroidlike follicular RCC, and RCC in neuroblastoma survivors. 27684973 2016
Entrez Id: 238
Gene Symbol: ALK
ALK
0.400 GeneticVariation disease BEFREE These are likely to be incorporated into subsequent classifications and include thyroid-like follicular RCC, succinate dehydrogenase B mutation-associated RCC, ALK translocation RCC, tuberous sclerosis complex-associated RCC, and RCC with (angio) leiomyomatous stroma. 25753529 2015
Entrez Id: 238
Gene Symbol: ALK
ALK
0.400 GeneticVariation disease BEFREE There have been recent reports of a rare variant of renal cell carcinoma associated with upregulation of the anaplastic lymphoma kinase gene (ALK) arising as a consequence of chromosomal translocations. 24318419 2014
Entrez Id: 238
Gene Symbol: ALK
ALK
0.400 AlteredExpression disease BEFREE Among the known major crizotinib targets MET, ALK, and ROS-1, only MET was expressed in our ccRCC cell line. 24929890 2014
Entrez Id: 238
Gene Symbol: ALK
ALK
0.400 Biomarker disease BEFREE VCL-ALK renal cell carcinoma may represent the eighth sickle-cell nephropathy. 24698962 2014
Entrez Id: 238
Gene Symbol: ALK
ALK
0.400 Biomarker disease CTD_human ALK alterations in adult renal cell carcinoma: frequency, clinicopathologic features and outcome in a large series of consecutively treated patients. 22743654 2012