Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.380 | GeneticVariation | disease | BEFREE | To facilitate the development of molecular based diagnostic tools and targeted therapies for this aggressive kidney cancer, we generated a translocation RCC mouse model, in which the <i>PRCC-TFE3</i> transgene is expressed specifically in kidneys leading to the development of RCC with characteristic histology. | 31043488 | 2019 | ||||
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0.380 | GeneticVariation | disease | BEFREE | Herein, we identify a case of MITF translocation RCC with the novel PRCC-MITF gene fusion by RNA sequencing. | 29148086 | 2018 | ||||
|
0.380 | Biomarker | disease | BEFREE | All 7 PRCC-TFE3 RCCs showed positive cathepsin K immunoreactivity. | 28949976 | 2017 | ||||
|
0.380 | Biomarker | disease | BEFREE | We corroborate prior data showing that the PRCC-TFE3 RCCs are the only known Xp11 translocation RCC molecular subtype that are consistently cathepsin K positive. | 26975036 | 2016 | ||||
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0.380 | Biomarker | disease | BEFREE | PRCC-TFE3 renal cell carcinoma in a boy with a history of contralateral mesoblastic nephroma. | 16807766 | 2006 | ||||
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0.380 | AlteredExpression | disease | BEFREE | The endothelin axis was expressed differently in the two main subtypes of RCC and appeared to match macroscopic features commonly observed in these tumors (i.e., high expression of PPET-1 in hypervascular ccRCC contrasted against low PPET-1 and ET(A) expression in hypovascular PRCC). | 15139053 | 2004 | ||||
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0.380 | Biomarker | disease | BEFREE | A PRCC-TFE3 fusion gene is typically encountered in t(X;1)-positive non-familial papillary RCCs and results in abrogation of the cell cycle mitotic spindle checkpoint in a dominant-negative fashion, thus leading to RCC. | 12351585 | 2002 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | The papillary renal cell carcinoma (RCC)-associated (X;1)(p11;q21) translocation fuses the genes PRCC and TFE3 and leads to cancer by an unknown molecular mechanism. | 11717438 | 2001 | ||||
|
0.380 | Biomarker | disease | CTD_human |