Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE PTEN expression and mutations in TSC1, TSC2 and MTOR are associated with response to rapalogs in patients with renal cell carcinoma. 31335987 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE The MTT assay revealed that miR-130b modulated cell growth. qRT-PCR revealed an inverse correlation between miR-130b and PTEN in RCC. 31195398 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Further studies verified that PTEN deficiency effectively attenuated the ability of AFAP1-AS1 in promoting ccRCC cell proliferation, invasion, migration, and EMT. 30832752 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Long noncoding RNA lnc-DILC stabilizes PTEN and suppresses clear cell renal cell carcinoma progression. 31592114 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE Our findings have indicated that multiple genes and pathways may play a crucial role in PTEN mutation ccRCC, offering candidate targets and strategies for PTEN mutation ccRCC individualized treatment. 31139560 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE The expression pattern of tumor suppressor gene phosphatase and tensin homolog deleted on chromosome ten (PTEN) and phosphatase and tensin homolog deleted on chromosome ten/phosphatidylinositol3-kinase/protein kinase B (PTEN/PI3K/AKT) cell signaling pathway in renal cell carcinoma (RCC) were investigated in children. 30655739 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE Expression levels of PTEN-Long in serum of patients with nephritis, renal cell carcinoma (RCC) as well as normal controls, and in serum and renal tissues of mice were measured by western blotting. 30680021 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Therefore, the purpose of this work was to (1) evaluate the expression of EMT markers: ZEB2, vimentin, N-cadherin, TWIST, PTEN, survivin, E-cadherin, Ki-67 and GLUT-1, (2) assess mutation status of two genes: PIK3CA and KRAS, and (3) investigate the potential relationships between the studied biomarkers and clinicopathological factors in clear-cell renal cell carcinoma (ccRCC). 30569446 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE Clear cell renal cell carcinoma: identifying PTEN expression on multiphasic MDCT. 29946925 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE The PTEN expressing RCC cell line A498 and the PTEN deficient 786-O cell line were stably transfected with the PTEN-Δ or PTEN transcript. 29954386 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE In summary, we conclude that DLX6-AS1 promotes renal cell carcinoma development via regulation of miR-26a/PTEN axis. 28881158 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Taken together, the findings indicated for the first time that miR-193a-3p functions as a tumor-promoting microRNA by directly targeting PTEN in renal cell carcinoma. 28639901 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE This meta-analysis suggests that PTEN expression is of limited value in predicting the prognosis of patients with RCC for OS and PFS via immunohistochemistry staining analysis; and that for DSS, low PTEN expression is significantly associated with an unfavorable outcome. 28672019 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE miR‑205 suppresses cell proliferation, invasion, and metastasis via regulation of the PTEN/AKT pathway in renal cell carcinoma. 27498834 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE In conclusion, the present study suggested that the miR-22/PTEN axis may be considered a novel therapeutic target in RCC. 27082730 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE In ccRCC tissues, expression levels of SMAD4 and PTEN were negatively correlated with expression level of miR-19a, revealing that miR-19a suppressed the expression of SMAD4 and PTEN in ccRCC patients. miR-19a overexpression significantly suppressed the expression of SMAD4 and PTEN in vitro, further verifying that SMAD4 and PTEN were the target genes of miR-19a in ccRCC cells. 27779660 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE Depletion of the triggering receptor expressed on myeloid cells 2 inhibits progression of renal cell carcinoma via regulating related protein expression and PTEN-PI3K/Akt pathway. 27779645 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE We excluded the samples that had any of the five high-confidence driver genes (VHL, BAP1, SETD2, PTEN and KDM5C) reported in ccRCC to avoid their possible influence in our results. 27556922 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE Gain of function experiments showed overexpression of PTEN-Long in the ccRCC cell line 786-0 suppressed PI3K-Akt signaling, inhibited cell proliferation, migration and invasion, and eventually induced cell death. 25714556 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE Changes in PTEN and CDKN2A gene sets were associated with worsened prognosis of ccRCC. 25853938 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE This was further verified in CCRCC tissue specimens from patients The results of the present study suggested that loss of PTEN, which deactivated Akt/HDM2 signaling followed by degradation of p53, may contribute to the development of etoposide resistance in CCRCC. 25954860 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease CTD_human Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes. 25401301 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE Of 416 patients with clear cell renal cell carcinoma 11 (2.6%) had biallelic PTEN loss and 69 (16.6%) had monoallelic loss. 24704020 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE PTENP1 and PTEN are direct targets of miRNA miR21 and their expression is suppressed by miR21 in ccRCC cell lines. miR21 expression promotes ccRCC cell proliferation, migration, invasion in vitro, and tumor growth and metastasis in vivo. 25249556 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Because loss of PTEN can activate mTOR and mTOR inhibitors are Food and Drug Administration approved to treat renal cell carcinoma, these agents have clinical potential in renal cell carcinoma associated with Cowden syndrome. 23764071 2013