Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6760
Gene Symbol: SS18
SS18
0.100 Biomarker disease BEFREE The SS18 (SYT) gene rearrangement is useful for confirming the SS diagnosis. 30789354 2020
Entrez Id: 727837
Gene Symbol: SSX2B
SSX2B
0.100 GeneticVariation disease BEFREE Apart from the canonical SS18-SSX fusion, this is only the second alternative gene fusion variant described in synovial sarcoma to date, in addition to two cases harboring the SS18L1-SSX1 fusion. 31595587 2020
Entrez Id: 6757
Gene Symbol: SSX2
SSX2
0.100 GeneticVariation disease BEFREE Apart from the canonical SS18-SSX fusion, this is only the second alternative gene fusion variant described in synovial sarcoma to date, in addition to two cases harboring the SS18L1-SSX1 fusion. 31595587 2020
Entrez Id: 7088
Gene Symbol: TLE1
TLE1
0.100 AlteredExpression disease BEFREE TLE1 expression fails to distinguish between synovial sarcoma, atypical fibroxanthoma, and dermatofibrosarcoma protuberans. 31614009 2020
Entrez Id: 6760
Gene Symbol: SS18
SS18
0.100 GeneticVariation disease BEFREE Apart from the canonical SS18-SSX fusion, this is only the second alternative gene fusion variant described in synovial sarcoma to date, in addition to two cases harboring the SS18L1-SSX1 fusion. 31595587 2020
Entrez Id: 6760
Gene Symbol: SS18
SS18
0.100 Biomarker disease BEFREE Investigation of SS18 status to exclude synovial sarcoma is suggested prior to rendering a diagnosis of spindle cell adamantinoma. 30206413 2019
Entrez Id: 6757
Gene Symbol: SSX2
SSX2
0.100 Biomarker disease BEFREE Interestingly, three SS18 fusion genes (SS18-SSX2B, SS18-SSX2, and SS18-SSX4) were identified in a synovial sarcoma case. 31232935 2019
Entrez Id: 7088
Gene Symbol: TLE1
TLE1
0.100 Biomarker disease BEFREE Overall, immunohistochemistry for NKX2.2 and TLE1 can provide a useful first step in helping to distinguish EWS and SS. 28800015 2019
Entrez Id: 6760
Gene Symbol: SS18
SS18
0.100 Biomarker disease BEFREE The diagnosis of primary renal synovial sarcoma requires histopathology and the confirmation of SYT-SSX gene fusion using molecular techniques. 31367627 2019
Entrez Id: 6857
Gene Symbol: SYT1
SYT1
0.100 GeneticVariation disease BEFREE Fluorescence in situ hybridization performed on the cell block demonstrated the presence of SYT (18q11) translocation, supporting the diagnosis of synovial sarcoma. 31173483 2019
Entrez Id: 6757
Gene Symbol: SSX2
SSX2
0.100 AlteredExpression disease BEFREE The diagnosis of primary renal synovial sarcoma requires histopathology and the confirmation of SYT-SSX gene fusion using molecular techniques. 31367627 2019
Entrez Id: 6760
Gene Symbol: SS18
SS18
0.100 Biomarker disease BEFREE SS18-SSX-Dependent YAP/TAZ Signaling in Synovial Sarcoma. 30814111 2019
Entrez Id: 6760
Gene Symbol: SS18
SS18
0.100 GeneticVariation disease BEFREE Fluorescence in situ hybridization performed on the cell block demonstrated the presence of SYT (18q11) translocation, supporting the diagnosis of synovial sarcoma. 31173483 2019
Entrez Id: 6760
Gene Symbol: SS18
SS18
0.100 Biomarker disease BEFREE Interestingly, three SS18 fusion genes (SS18-SSX2B, SS18-SSX2, and SS18-SSX4) were identified in a synovial sarcoma case. 31232935 2019
Entrez Id: 727837
Gene Symbol: SSX2B
SSX2B
0.100 AlteredExpression disease BEFREE The diagnosis of primary renal synovial sarcoma requires histopathology and the confirmation of SYT-SSX gene fusion using molecular techniques. 31367627 2019
Entrez Id: 6857
Gene Symbol: SYT1
SYT1
0.100 Biomarker disease BEFREE The diagnosis of primary renal synovial sarcoma requires histopathology and the confirmation of SYT-SSX gene fusion using molecular techniques. 31367627 2019
Entrez Id: 7088
Gene Symbol: TLE1
TLE1
0.100 Biomarker disease BEFREE Therefore, TLE1 is not a specific biomarker for synovial sarcoma and should be evaluated with caution, particularly in cases in which the differential diagnosis may include other cutaneous tumors. 30608261 2019
Entrez Id: 6760
Gene Symbol: SS18
SS18
0.100 AlteredExpression disease BEFREE These findings explain the skeletal contact frequently observed in human SS and may provide alternate means of enabling SS18-SSX-driven oncogenesis in cells as differentiated as preosteoblasts. 29202462 2018
Entrez Id: 6757
Gene Symbol: SSX2
SSX2
0.100 Biomarker disease BEFREE We demonstrate that BRD9 supports oncogenic mechanisms underlying the SS18-SSX fusion in synovial sarcoma and highlight targeted degradation of BRD9 as a potential therapeutic opportunity in this disease. 30431433 2018
Entrez Id: 6760
Gene Symbol: SS18
SS18
0.100 Biomarker disease BEFREE In this study, we conducted proteomic studies using <i>SS18</i>/<i>SSX</i> knockdown in three SS cell lines to identify the regulated proteins associated with SS18/SSX in SS. 30680066 2018
Entrez Id: 727837
Gene Symbol: SSX2B
SSX2B
0.100 Biomarker disease BEFREE Epigenetic ConFUSION: SS18-SSX Fusion Rewires BAF Complex to Activate Bivalent Genes in Synovial Sarcoma. 29894696 2018
Entrez Id: 6857
Gene Symbol: SYT1
SYT1
0.100 GeneticVariation disease BEFREE Synovial sarcoma is an aggressive sarcoma with specific reciprocal chromosomal translocation of SS18 (also known as SYT) and SSX genes. 27362474 2018
Entrez Id: 6757
Gene Symbol: SSX2
SSX2
0.100 AlteredExpression disease BEFREE Additionally, we showed that SS can originate from periosteal cells expressing SS18-SSX alone and from preosteoblasts expressing the fusion oncogene accompanied by the added stabilization of β-catenin, which is a common secondary change in SS. 29202462 2018
Entrez Id: 6760
Gene Symbol: SS18
SS18
0.100 Biomarker disease BEFREE Epigenetic ConFUSION: SS18-SSX Fusion Rewires BAF Complex to Activate Bivalent Genes in Synovial Sarcoma. 29894696 2018
Entrez Id: 7088
Gene Symbol: TLE1
TLE1
0.100 Biomarker disease BEFREE We evaluated TLE-1 and CD99 expression in various carcinomas and evaluated the expression of the SS18 (SYT) gene rearrangement (a characteristic biomarker for synovial sarcoma) in tumors with TLE-1 and/or CD99 expression. 27753659 2018