Angiosarcomas in <i>aP2-Cre;Dicer1<sup>Flox/-</sup></i> mice histologically and genetically resemble human angiosarcoma. miR-23 target genes, including the oncogenes <i>Ccnd1</i> as well as <i>Adam19, Plau</i>, and <i>Wsb1</i> that promote invasiveness and metastasis, were enriched in mouse and human angiosarcoma.