Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker phenotype BEFREE The adaptation of solid tumors to the low oxygen/nutrient environment is mediated by the pivotal transcription role of hypoxia-inducible factor-1 (HIF-1). 29960020 2018
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker phenotype BEFREE In this review, we discuss the distinct and overlapping roles of HIF-1 and Nrf2 in the cellular response to hypoxia, with a focus on how targeting Nrf2 could provide novel chemotherapeutic modalities for treating solid tumors. 28383481 2017
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 AlteredExpression phenotype BEFREE The HIF-1 level is often upregulated in the hypoxic microenvironment of solid tumors, which contributes to cancer treatment failure. 27994464 2017
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker phenotype BEFREE Potential implication and application of the stress-facilitated HIF-1 activation in solid tumors and ischemic disorders will be discussed. 26206147 2016
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker phenotype BEFREE Although the function of hypoxia-inducible factor 1 (HIF1) in many kinds of solid tumor has been revealed, the significance of HIF1 in osteosarcoma is still controversial and not well understood. 26077139 2015
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker phenotype BEFREE HIF-1 (hypoxia-inducible factor 1) activation is critical for the metabolic reprogramming and progression of solid tumors, and DEC2 (differentiated embryonic chondrocyte gene 2) has been recently reported to suppress HIF-1 in human breast and endometrial cancers. 25884381 2015
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker phenotype BEFREE Hypoxia is a common phenomenon in the development of solid tumors, and hypoxia inducible factor 1 (HIF-1) plays a central role in coordinating the cellular response to hypoxia and in oxygen homeostasis. 24894671 2014
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 AlteredExpression phenotype BEFREE Hypoxia-inducible factor-1 (HIF-1) is a key heterodimeric transcription factor for the cellular adaptive response to hypoxia, a common feature of the microenvironment in solid tumors. 24916276 2014
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker phenotype BEFREE The HIF1- and HIF2-mediated transcriptional responses play critical roles in solid tumor progression. 23991099 2013
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker phenotype BEFREE Our results revealed that Nox4 was predominantly highly expressed in the endogenous cycling hypoxic areas with HIF-1 activation and blood perfusion within the solid tumor microenvironment. 22713363 2012
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker phenotype BEFREE HIF-1 is the key cellular survival protein under hypoxia, and is associated with tumor progression and metastasis in various solid tumors. 20627616 2011
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 AlteredExpression phenotype BEFREE Hypoxia is the hallmark of solid tumors and contributes to tumor angiogenesis mainly through activation of the transcription factor hypoxia-inducible factor-1 (HIF-1). 21048308 2010
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 AlteredExpression phenotype BEFREE All of these results indicate that Akt/mTOR-dependent translation of HIF-1alpha plays a critical role in the postirradiation up-regulation of intratumoral HIF-1 activity in response to radiation-induced alterations of glucose and oxygen availability in a solid tumor. 19098000 2009
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker phenotype BEFREE Hypoxia and signaling via hypoxia-inducible factor-1 (HIF-1) is a key feature of solid tumors and is related to tumor progression as well as treatment failure. 19240180 2009
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker phenotype BEFREE Hypoxia-inducible factor-1 (HIF-1) is an important tumor-selective therapeutic target for solid tumors. 17980359 2008
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker phenotype BEFREE Hypoxia-inducible factor 1 (HIF-1) controls angiogenesis and glycolysis, two leading characteristics of solid tumor invasion, metastasis, and lethality. 15014526 2004