Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.100 Biomarker phenotype BEFREE Preclinical Antitumor Activity of a Novel Anti-c-KIT Antibody-Drug Conjugate against Mutant and Wild-type c-KIT-Positive Solid Tumors. 29764854 2018
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.100 AlteredExpression phenotype BEFREE Imatinib mesylate is a chemotherapeutic drug that inhibits the tyrosine kinase activity of c-KIT and has been successfully used to treat leukemias and some solid tumors. 25786656 2015
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.100 GeneticVariation phenotype BEFREE They have represented a paradigm of molecular-targeted therapies for solid tumors since the discovery of KIT mutations and KIT expression in GIST in 1998, which opened the way to the use of imatinib, a tyrosine kinase inhibitor able to inhibit the growth of cells expressing KIT-mutant isoforms. 23975171 2013
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.100 AlteredExpression phenotype BEFREE Sunitinib is a clinically approved multitargeted tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptor, c-KIT, and PDGFR, and has shown clinical activity in various solid tumors. 19366796 2009
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.100 Biomarker phenotype BEFREE Notably, most pediatric KIT-wild-type GISTs progress to malignancy without acquiring large-scale chromosomal aberrations, which is a phenomenon not reported previously in malignant solid tumors. 17909012 2007
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.100 GeneticVariation phenotype BEFREE We therefore evaluated the effects of imatinib mesylate (imatinib), a selective inhibitor of the c-kit and PDGFR tyrosine kinases, on the growth of rodent Leydig tumor cell lines in vivo and in vitro, and examined, in human Leydig cell tumor samples, the expression of activated PDGFR and c-kit and the mutations in exons of the c-kit gene commonly associated with solid tumors. 15753388 2005
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.100 AlteredExpression phenotype BEFREE The tyrosine-kinase receptor c-kit (CD117) and its ligand stem cell factor are considered to be co-expressed in various solid tumors, including adenocarcinomas of the lung. 15627886 2005
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.100 GeneticVariation phenotype BEFREE KIT and platelet-derived growth factor receptor alpha tyrosine kinase gene mutations and KIT amplifications in human solid tumors. 15545668 2005
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.100 Biomarker phenotype BEFREE KIT and platelet-derived growth factor receptors (PDGFRs) play critical oncogenic roles in a broad spectrum of hematologic and solid tumors. 15175998 2004
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.100 Biomarker phenotype BEFREE Some KIT-overexpressing solid tumors have responded favorably to STI571, potentially because of the presence of KIT-activating mutations. 14734467 2004
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.100 Biomarker phenotype BEFREE The results suggest that the c-kit gene products may be involved in the pathogenesis of a very restricted subset of human solid tumors such as small cell lung cancer. 7678721 1993
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.100 Biomarker phenotype BEFREE These data show that some human solid tumor cell lines display high-affinity c-kit receptors and produce SCF, which can be detected on the cell surface. 1378316 1992