Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE The p53 gene is the most commonly mutated gene in solid tumors, but leveraging p53 status in therapy remains a challenge. 30679201 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE Phase 1 study of the MDM2 inhibitor AMG 232 in patients with advanced P53 wild-type solid tumors or multiple myeloma. 31359240 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors. 31795192 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Biallelic TP53 gain of function mutations in rapidly progressing solid tumors. 29666004 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Although p53 mutations are common in solid tumors, such mutations are found at a lower frequency in hematologic malignancies. 29784053 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE Tumor suppressor protein p53 aggregates in the hypoxic core of solid tumors. 29953728 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 PosttranslationalModification phenotype BEFREE Taken together, our results suggest that MMSET is a regulator of p53 stability via methylation of AURKA in proliferating cells and might be a potential therapeutic target in solid tumors. 30013191 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE In dose escalation, patients with any locally advanced/metastatic solid tumour with TP53 mutation prevalence below 40%, or documented as TP53 wild-type, were eligible. 28324749 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE Purpose To evaluate MK-8242 in patients with wild-type TP53 advanced solid tumors. 28240971 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE The tumor suppressor p53 is inactivated by mutations in the majority of human solid tumors. 27327543 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE Safety and Efficacy in Advanced Solid Tumors of a Targeted Nanocomplex Carrying the p53 Gene Used in Combination with Docetaxel: A Phase 1b Study. 27357628 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE In patients with detected hotspot TP53 mutant advanced solid tumors (n = 11), the treatment led to a 45% rate of SD ≥6 months/PR (1 PR and 3 SD ≥6 months), median PFS of 3.5 months, and median OS of 12.7 months, compared favorably with the results for patients with undetected hotspot TP53 mutations (n = 25): 16% (1 PR and 3 SD ≥6 months, P = 0.096), 2.0 months (P = 0.042), and 7.4 months (P = 0.1), respectively. 25669829 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE These studies showed that TP53 and PI3KCA are the two most mutated genes in all types of cancers and that 30-70% of all solid tumors harbor potentially 'actionable' mutations that can be exploited for patient stratification or treatment optimization. 24833724 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Nutlin-3 has been proposed as an anti-neoplastic agent for the treatment of onco-hematological diseases characterized by a lower incidence of p53 mutation with respect to solid tumors. 23627936 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE Phase I study of a systemically delivered p53 nanoparticle in advanced solid tumors. 23609015 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Clinical implications of TP53 polymorphisms have been reported for several diseases, including a variety of solid tumors and endometriosis. 22353881 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE In NF1 syndrome, loss of p53 function is a common event in solid tumors, but uncommon in JMML, suggesting that the p53 pathway may be modified by other events in this hematopoietic disorder. 21681782 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE It binds to and inhibits key proteins like p53 and the RB protein, and MDM2 amplification as well as protein overexpression without amplification is seen in many solid tumors. 21436469 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression phenotype BEFREE For assessment of p53 and PCNA positivity, the number of positively stained cells with brown-stained nuclei was counted in 1000 cells from each sample. p53 and PCNA expression in the solid neoplasm subtype were significantly higher when compared to cystic neoplasm and simple cyst (P < 0.05). 21206164 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression phenotype BEFREE In this study we show that p53 is required for the downregulation of FoxM1, an essential transcription factor that regulates many G2/M-specific genes and is overexpressed in a multitude of solid tumors. 19749794 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Among the natural sequence variants of TP53, rs1042522 (R72P) modifies the risk for solid tumors. 19837266 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE The results of a phase I clinical trial of the topoisomerase I (Topo I) poison CPT-11 followed by the cyclin-dependent kinase inhibitor flavopiridol in patients with advanced solid tumors indicate that patients whose tumors were wild-type, but not mutant, for p53 obtained the most clinical benefit from this combination therapy. 18381438 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE A single nucleotide polymorphism (SNP) at position 309 in the promoter region of MDM2 leading to increased expression of MDM2 and attenuated function of p53 has been negatively associated with onset and outcome of disease in solid tumors. 18467716 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Mutations in codon 72 of TP53 have been studied in breast cancer and most solid tumors. 17284368 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE In pediatric solid tumors, such as neuroblastoma (NB), it has been reported that the frequency of TP53 gene alterations is lower than that in adult tumors, suggesting that other tumor suppressor genes may play more important roles in the development of pediatric solid tumors. 15942682 2005