Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.390 Biomarker disease BEFREE Structural maintenance of chromosomes 4 is required for leukemia stem cell maintenance in MLL-AF9 induced acute myeloid leukemia. 29043883 2018
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.390 AlteredExpression disease BEFREE ChIP-Seq/qPCR analysis in MLL-r mouse models revealed aberrant epigenetic modifications with increased H3K79me2, and decreased H3K9me3 and H3K27me3 levels in LSCs, which may account for the high expression levels of Pbx3. 28411381 2017
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.390 AlteredExpression disease BEFREE Low endogenous Id2 expression is associated with LSC enrichment while Id2 overexpression impairs MLL-AF9-leukemia initiation and growth. 27374225 2016
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.390 Biomarker disease BEFREE La-related protein 4B maintains murine MLL-AF9 leukemia stem cell self-renewal by regulating cell cycle progression. 25534202 2015
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.390 Biomarker disease BEFREE The H3K4-specific demethylase KDM5B negatively regulates leukemogenesis in murine and human MLL-rearranged AML cells, demonstrating a crucial role for the H3K4 global methylome in determining LSC fate. 26190263 2015
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.390 Biomarker disease BEFREE Focusing on MLL-mutated AML as an exemplar, Epc1 or Epc2 KD-induced apoptosis of murine MLL-AF9 AML cells and abolished leukemia stem cell potential. 24166297 2014
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.390 Biomarker disease BEFREE The NF-κB subunit RELA occupies promoter regions of crucial MLL target genes and sustains the MLL-dependent leukemia stem cell program. 24054986 2013
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.390 Biomarker disease BEFREE We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. 20541704 2010
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.390 Biomarker disease BEFREE Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. 17942707 2007
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.390 FusionGene disease ORPHANET We report a novel MLL-associated chromosome translocation t(11;14)(q23;q24) in a child who showed signs of acute undifferentiated leukemia 3 years after intensive chemotherapy that included the topoisomerase-II inhibitor VP 16. 11579461 2001