Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6886
Gene Symbol: TAL1
TAL1
0.060 Biomarker disease BEFREE SCL/TAL1 (stem cell leukemia/T-cell acute lymphoblastic leukemia [T-ALL] 1) is an essential transcription factor in normal and malignant hematopoiesis. 28179281 2017
Entrez Id: 6886
Gene Symbol: TAL1
TAL1
0.060 Biomarker disease BEFREE Actually, in patients, SCL transcription initiated at promoter 1b is restricted to primitive CD34+CD41- progenitor cells, while it is detectable in both cell subsets from healthy subjects; (iii) the full-length isoform of SCL protein is present in patients' CD34+ cells and in PBMC; in the latter the SCL-expressing cells mainly belong to the MK lineage in which its sublocalization is both nuclear and cytoplasmic, which contrasts with the sole nuclear staining observed in normal MK cells. 14513050 2003
Entrez Id: 6886
Gene Symbol: TAL1
TAL1
0.060 GeneticVariation disease BEFREE The interstitial deletion at 1p32 involving SIL (SCL-interrupting locus)/SCL (stem cell leukemia) is a case involving two non-V(D)J sites that have been suggested to be V(D)J recombination mistakes. 11390401 2001
Entrez Id: 6886
Gene Symbol: TAL1
TAL1
0.060 GeneticVariation disease BEFREE The SCL gene, initially discovered at the site of a translocation breakpoint associated with the development of a stem cell leukemia, encodes a protein that contains the highly conserved basic helix-loop-helix (bHLH) motif found in a large array of eukaryotic transcription factors. 1311214 1992
Entrez Id: 6886
Gene Symbol: TAL1
TAL1
0.060 GeneticVariation disease BEFREE We have identified the human gene, SCL.We discovered this gene because of its involvement in a chromosomal translocation associated with the occurrence of a stem cell leukemia manifesting myeloid and lymphoid differentiation capabilities. 2602361 1990
Entrez Id: 6886
Gene Symbol: TAL1
TAL1
0.060 Biomarker disease BEFREE This translocation may identify a gene for which we propose the name SCL (stem-cell leukemia) that is important for hemopoietic development and oncogenesis and that has been disrupted or altered in this stem-cell line. 2467296 1989