Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE TRAF6 correlated to invasion and poor prognosis of glioblastoma via elevating MMP9 expression. 30571666 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE Downregulation of the miR-221/222 cluster diminished the invasion, migration, proliferation, and angiogenesis with reduced protein levels of matrix metalloproteinase-2 (MMP-2), MMP-9, and vascular endothelial growth factor in glioblastoma cells. 31106423 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE Delineation of crosstalk between HSP27 and MMP-2/MMP-9: A synergistic therapeutic avenue for glioblastoma management. 31028823 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE We analysed the transcript expression of CLEC5A in glioblastoma by accessing The Cancer Genome Atlas (TCGA). qRT-PCR was performed to detect the RNA expression of genes in cells and tissues, and Western blot was used to measure the protein levels (Cyclin D1, Bcl-2, BAX, PCNA, MMP2, MMP9, Akt and Akt phosphorylation) in tissues and cells. 30834619 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Activation of PI3K/AKT signaling prevented the suppressive effects of RWDD3 downregulation on glioblastoma cell proliferation and migration, concurrent with increased protein levels of MMP2 and MMP9. 29977365 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Voxel-based statistical analysis revealed the anatomical specificity of MMP-9 expression levels in glioblastoma. 29187298 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Glioblastoma xenograft tumors treated with VB showed elevated SHP-1, Bax, cleaved caspase-3, and cleaved PARP expression and reduced p-STAT3, Bcl-2, survivin, MMP-2, and MMP-9 expression. siRNA-SHP-1 inhibited the VB effects on glioblastoma. 29961065 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 GeneticVariation disease BEFREE We investigated the roles of these in the regulation of MMP-2 and MMP-9 in human glioblastoma T-98G cells. 28112361 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE These experimental data suggested that the overexpression of MMP9 in glioblastoma cells may occur primarily through an increase in gene copy number. 28454256 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE The results obtained in the present study signified the importance of some genes, such as COL3A1, FN1, and MMP9, for glioblastoma. 28191466 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE Luteolin treatment significantly inhibited glioblastoma cell migration, and this effect was associated with downregulated matrix metalloproteinase (MMP)-2, MMP-9 and upregulated tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2. 28927111 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE The expression of EGFR and MMP9 was upregulated in glioblastoma tissues compared to their normal tissues. 27621042 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE Moreover, ATO significantly increased adhesion of U87MG cells and also diminished transcription of NF-κB down-stream targets involved in cell migration and invasion, including cathepsin B, uPA, MMP-2, MMP-9 and MMP-14 and suppressed proteolytic activity of cathepsin B, MMP-2 and MMP-9, demonstrating a possible mechanism of ATO effect on a well-known signaling in glioblastoma dissemination. 27039805 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE These results demonstrate that miRNA-146a acts as a novel regulator to modulate the activity and transduction of TGF-β signaling pathways in glioblastoma, and the downregulation of miRNA-146a is required for overexpression of EGFR and MMP9, which can be considered an efficiently therapeutic target and a better understanding of glioblastoma pathogenesis. 25326894 2015
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE Taken together, these findings suggest that EGF/EGFR signaling activates downstream PI-3 K/Akt to induce FoxO1 nuclear exclusion, which activates MMP9 to promote glioblastoma invasiveness. 24771221 2014
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Taken together, these findings suggest that EGFR signaling activates downstream PI3K/Akt to increase MMP9 expression in glioblastoma, while phosphorylation of Akt is a control point by miRNA-181c. 24867100 2014
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE MMP-9 induces CD44 cleavage and CD44 mediated cell migration in glioblastoma xenograft cells. 22024282 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Further research into the underlying mechanism demonstrated that the effects of miR-125b on the invasion of glioblastoma CD133-positive cells were associated with the alteration of the expression of MMPs (MMP-2 and MMP-9) and corresponding inhibitors (RECK and TIMP3). 22711523 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE An extensive invasive intracranial human glioblastoma xenograft model: role of high level matrix metalloproteinase 9. 20413683 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Additionally, suppression of TPA-induced PKCalpha/ERK/NK-kappaB activation, migration, and MMP-9 activation by flavonoids including kaempferol (Kae; 3,5,7,4'-tetrahydroxyflavone), luteolin (Lut; 5,7,3'4'-tetrahydroxyflavone), and wogonin (Wog; 5,7-dihydroxy-8-methoxyflavone) was demonstrated, and structure-activity relationship (SAR) studies showed that hydroxyl (OH) groups at C4' and C8 are critical for flavonoids' action against MMP-9 enzyme activation and migration/invasion of glioblastoma cells elicited by TPA. 20458747 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE Additionally, disruption of lipid rafts with methyl β cyclodextrin prevented Fas clustering and pU-Si-, pM-Si-, or pUM-Si-induced apoptosis, which is indicative of coclustering of Fas death receptor into lipid rafts in the glioblastoma xenograft cell lines 4910 and 5310. 20716639 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Together, our data strongly suggest that LRP1 promotes glioblastoma cell migration and invasion by regulating the expression and function of MMP2 and MMP9 perhaps via an ERK-dependent signaling pathway. 19176371 2009
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE We found that glioblastoma tumors escaped from antiangiogenic treatment by (a) reactivating angiogenesis through up-regulation of other proangiogenic factors and (b) invading normal brain areas, which was seen in association with up-regulation of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-12; secreted protein, acidic, cysteine-rich; and tissue inhibitor of metalloproteinase 1. 19567589 2009
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE The regulating role of mutant IkappaBalpha in expression of TIMP-2 and MMP-9 in human glioblastoma multiform. 19187648 2009
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Transfection of a plasmid vector-expressing double-stranded RNA (dsRNA) for MMP-9 and cathepsin B significantly inhibited MMP-9 and cathepsin B expression and reduced the invasive behavior of SNB19, glioblastoma cell line in Matrigel and spheroid invasion models. 15122332 2004