Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.120 GeneticVariation disease BEFREE TP53 and ATRX mutations can be important mechanisms in the pathogenesis of u-LMS and are correlated with a poor prognosis. 29660202 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.120 GeneticVariation disease BEFREE We showed that conditional deletion of p53 in mice results in the development of uterine tumors that resemble human ULMS and that concurrent deletion of p53 and BRCA1 significantly accelerates the progression of these tumors. 19843854 2009
Entrez Id: 2271
Gene Symbol: FH
FH 		0.120 GeneticVariation disease BEFREE This study shows that FH germline mutations can occur in seemingly nonsyndromic cases of ULMS (1/67, 1.5%). 16477632 2006
Entrez Id: 2271
Gene Symbol: FH
FH 		0.120 GeneticVariation disease BEFREE The present study confirms with calculated risk ratios the association of early onset RCC and ULMS with FH germline mutations in Finns. 16155190 2006
Entrez Id: 2271
Gene Symbol: FH
FH 		0.120 Biomarker disease HPO
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.120 Biomarker disease HPO
Entrez Id: 207
Gene Symbol: AKT1
AKT1 		0.100 Biomarker disease HPO
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.100 Biomarker disease HPO
Entrez Id: 701
Gene Symbol: BUB1B
BUB1B 		0.100 Biomarker disease HPO
Entrez Id: 699
Gene Symbol: BUB1
BUB1 		0.100 Biomarker disease HPO
Entrez Id: 10395
Gene Symbol: DLC1
DLC1 		0.100 Biomarker disease HPO
Entrez Id: 6714
Gene Symbol: SRC
SRC 		0.100 Biomarker disease HPO
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.100 Biomarker disease HPO
Entrez Id: 2033
Gene Symbol: EP300
EP300 		0.100 Biomarker disease HPO
Entrez Id: 324
Gene Symbol: APC
APC 		0.100 Biomarker disease HPO
Entrez Id: 8313
Gene Symbol: AXIN2
AXIN2 		0.100 Biomarker disease HPO
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease HPO
Entrez Id: 1630
Gene Symbol: DCC
DCC 		0.100 Biomarker disease HPO
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3 		0.100 Biomarker disease HPO
Entrez Id: 201163
Gene Symbol: FLCN
FLCN 		0.100 Biomarker disease HPO
Entrez Id: 9968
Gene Symbol: MED12
MED12 		0.030 GeneticVariation disease BEFREE Expressions of cell cycle markers and hormone receptors, and MED12 mutations (12% in ULMSs) were not identified as prognostic markers in this study. 29077232 2018
Entrez Id: 9968
Gene Symbol: MED12
MED12 		0.030 GeneticVariation disease BEFREE In addition, whole-exome sequencing of u-LMS has confirmed and demonstrated frequent alterations in TP53, RB1, α-thalassemia/mental retardation syndrome X-linked (ATRX) and mediator complex subunit 12 (MED12). 29660202 2018
Entrez Id: 9968
Gene Symbol: MED12
MED12 		0.030 GeneticVariation disease BEFREE Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer. 23132392 2012
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.020 Biomarker disease BEFREE This study identifies an increased prevalence of functional <i>BRCA1/2</i> loss in patients with uterine leiomyosarcoma (uLMS). 30541756 2019
Entrez Id: 79187
Gene Symbol: FSD1
FSD1 		0.020 Biomarker disease BEFREE Tumor suppressive mechanisms of miR-1, seem to be inhibited in uLMS SK-UT-1 cells, maybe as part of the malignant transformation process. 29491084 2018