Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 Biomarker disease BEFREE Pancreatic adenocarcinoma (PDA) is an aggressive disease driven by oncogenic KRAS and characterized by late diagnosis and therapeutic resistance. 31048544 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE K-Ras mutations are a hallmark of human pancreatic adenocarcinoma (PDAC) and epithelial-mesenchymal-transition (EMT) is a driver of progression. 29308316 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE Long-term survivors of pancreatic adenocarcinoma show low rates of genetic alterations in KRAS, TP53 and SMAD4. 29103024 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE Switch in KRAS mutational status during an unusual course of disease in a patient with advanced pancreatic adenocarcinoma: implications for translational research. 28549417 2017
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting. 28259298 2017
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 Biomarker disease BEFREE Targeting of KRAS to treat pancreatic adenocarcinoma has been applied at different stages of RAS molecular intracellular processes: at the transcription level with antisense or interference RNA, at the posttranslational level with inhibitors of farnesyl transferase or anti-RAS vaccination peptides, and to target multiple signalling pathways using inhibitors of mitogen-activated protein kinase, phosphoinositide 3-kinase, AKT, mammalian target of rapamycin, RAF. 26735353 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE KRAS mutation status is associated with specific pattern of genes expression in pancreatic adenocarcinoma. 26161927 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE In summary, KRAS G12C mutations, TTF-1, and napsin A were associated with primary lung adenocarcinoma, whereas KRAS G12R mutations, CK20, and CDX2 favored pancreatic adenocarcinoma. 23887294 2014
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE KRAS mutations were identified in 26 of 36 PA cases (72.2%), while none were detected in the disease control and/or healthy group. 25605154 2014
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE We present a case of an individual who received vemurafenib for metastatic melanoma and experienced rapid growth of a pre-existing KRAS-mutant pancreatic adenocarcinoma. 24946815 2014
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE The results indicated that ZD55-lipocalin-2, which specifically expressed higher levels of lipocalin-2 in tumor cells, may serve as a potent anticancer drug for pancreatic cancer therapy, especially for patients who have pancreatic adenocarcinoma with KRAS mutations. 22517373 2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 Biomarker disease BEFREE Here we report increased expression of the putative pancreatic stem cell marker DCAMKL-1 in an established KRAS transgenic mouse model of pancreatic cancer and in human pancreatic adenocarcinoma. 21285251 2011
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE Pancreatic adenocarcinoma is a leading cause of cancer death with frequent KRAS mutations. 21677471 2011
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE Codon-12 KRAS point mutation was found in 66% of PADC samples. 19533561 2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE We, therefore, investigated if analysis for mutant kras gene in the EUS-FNAC aspirates supplements cytopathology for the diagnosis of pancreatic adenocarcinoma (PAC). 18090159 2008
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE LigAmp quantification of mutant KRAS2 in pancreatic juice differentiates pancreatic adenocarcinoma from chronic pancreatitis, and may be a useful early detection tool for pancreatic cancer. 18075308 2008
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma. 17354229 2007
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE We examined surgically resected formalin-fixed, paraffin-embedded primary pancreatic adenocarcinoma tissue blocks for the presence of activating point mutations at codon 12 and 13 of the K-ras gene. 15610449 2005
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE Mutation of the K-ras gene is an early event in the development of pancreatic adenocarcinoma and, therefore, RNA interference (RNAi) directed toward mutant K-ras could represent a novel therapy. 16046552 2005
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE The K-ras gene mutation has been shown in 17 (73,9%) cases with pancreatic adenocarcinoma which was significantly more often than in chronic pancreatitis - 9 (42,8%) (p<0,01). 15608367 2004
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE The point mutations of the K-ras gene occur in as high as 70-90% of the cases with adenocarcinoma of the pancreas and apparently represent one of the key and early events in the carcinogenesis. 13679043 2003
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE Clinical usefulness of KRAS mutational analysis in the diagnosis of pancreatic adenocarcinoma by means of endosonography-guided fine-needle aspiration biopsy. 12755843 2003
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE These findings suggest that detection of K-ras gene mutations in lymph nodes may be clinically useful to assess the accurate tumor staging and to stratify the patient with pancreatic adenocarcinoma who are at high or low risk for recurrence after curative surgery. 10811991 2000
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE Mutations in codon 12 of the K-ras gene were examined by mutant allele-specific amplification method using DNA extracted from surgical specimens and plasma samples of 21 patients with pancreatic adenocarcinoma. 9626473 1998