Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Germline BRCA1 and BRCA2 mutations are the most common gene mutations in familial pancreatic adenocarcinoma. 31612916 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.200 GeneticVariation disease BEFREE Germline BRCA1 and BRCA2 mutations are the most common gene mutations in familial pancreatic adenocarcinoma. 31612916 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.200 Biomarker disease BEFREE Germline variants in double-strand DNA damage repair (dsDDR) genes (e.g., BRCA1/2) predispose to pancreatic adenocarcinoma (PDAC) and may predict sensitivity to platinum-based chemotherapy and poly(ADP) ribose polymerase (PARP) inhibitors. 29961768 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease BEFREE Out of 33 TGCA studies, the effects of TP53 mutations were statistically significant in nine cancers (lung adenocarcinoma, hepatocellular carcinoma, head and neck squamous cell carcinoma, acute myeloid leukemia, clear cell renal cell carcinoma (RCC), papillary RCC, chromophobe RCC, uterine endometrial carcinoma, and thymoma) for survival time and in five cancers (pancreatic adenocarcinoma, hepatocellular carcinoma, chromophobe RCC, acute myeloid leukemia, and thymoma) for disease-free survival time. 30542790 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE The study was powered to identify genes with a cumulative pathogenic variant prevalence of at least 3%, which includes the most prevalent PC susceptibility gene, BRCA2. 31469826 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Are BRCA1 and BRCA2 gene mutation patients underscreened for pancreatic adenocarcinoma? 30636051 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.200 GeneticVariation disease BEFREE Are BRCA1 and BRCA2 gene mutation patients underscreened for pancreatic adenocarcinoma? 30636051 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 Biomarker disease BEFREE Pancreatic adenocarcinoma (PDA) is an aggressive disease driven by oncogenic KRAS and characterized by late diagnosis and therapeutic resistance. 31048544 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE K-Ras mutations are a hallmark of human pancreatic adenocarcinoma (PDAC) and epithelial-mesenchymal-transition (EMT) is a driver of progression. 29308316 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker disease BEFREE Here, we report the ability of rfhSP-D to induce apoptosis <i>via</i> TNF-α/Fas-mediated pathway regardless of the p53 status in human pancreatic adenocarcinoma using Panc-1 (p53<sup>mt</sup>), MiaPaCa-2 (p53<sup>mt</sup>), and Capan-2 (p53<sup>wt</sup>) cell lines. 29915574 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.200 GeneticVariation disease BEFREE This single arm, non-randomised, multicentre phase II trial evaluated the response rate of veliparib in patients with previously treated BRCA1/2- or PALB2-mutant pancreatic adenocarcinoma (PDAC). 29223478 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE Long-term survivors of pancreatic adenocarcinoma show low rates of genetic alterations in KRAS, TP53 and SMAD4. 29103024 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE Switch in KRAS mutational status during an unusual course of disease in a patient with advanced pancreatic adenocarcinoma: implications for translational research. 28549417 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE BRCA1/BRCA2 germ line (GL) mutation carriers with pancreatic adenocarcinoma (PDAC) may have distinct outcomes. 28183138 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.200 GeneticVariation disease BEFREE BRCA1/BRCA2 germ line (GL) mutation carriers with pancreatic adenocarcinoma (PDAC) may have distinct outcomes. 28183138 2017
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting. 28259298 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker disease BEFREE As in the data mining study in the TCGA databases, our study provides a new perspective to understand the genetic features of K-ras and p53 in pancreatic adenocarcinoma. 28742845 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.200 Biomarker disease BEFREE Our data indicate that sequencing of the entire 5'UTR of CDKN2A should be included in routine screening of PC cases with suspected inherited susceptibility. 29216274 2017
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.200 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 Biomarker disease BEFREE Targeting of KRAS to treat pancreatic adenocarcinoma has been applied at different stages of RAS molecular intracellular processes: at the transcription level with antisense or interference RNA, at the posttranslational level with inhibitors of farnesyl transferase or anti-RAS vaccination peptides, and to target multiple signalling pathways using inhibitors of mitogen-activated protein kinase, phosphoinositide 3-kinase, AKT, mammalian target of rapamycin, RAF. 26735353 2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.200 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.200 GeneticVariation disease BEFREE KRAS mutation status is associated with specific pattern of genes expression in pancreatic adenocarcinoma. 26161927 2015
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Screening for Pancreatic Adenocarcinoma in BRCA2 Mutation Carriers: Results of a Disease Simulation Model. 26844277 2015