×
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600
FusionGene
disease
ORPHANET
×
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600
GenomicAlterations
disease
CGI
×
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600
CausalMutation
disease
CGI
×
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.400
FusionGene
disease
ORPHANET
×
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600
Biomarker
disease
BEFREE
Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor .
8187063 1994
×
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.400
Biomarker
disease
BEFREE
DSRCT thus represents the third primitive sarcoma in which the EWS gene is involved and the first instance of recurrent rearrangement of a tumor suppressor gene, WT1, in a specific tumor type.8187063 1994
×
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600
Biomarker
disease
BEFREE
A genomic DNA fragment containing the EWS-WT1 gene fusion has been isolated from a desmoplastic small round cell tumor , and the breakpoint has been characterized.
7862627 1995
×
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600
Biomarker
disease
BEFREE
EWS and WT-1 gene fusion in desmoplastic small round cell tumor of the abdomen.
8522311 1995
×
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600
GeneticVariation
disease
BEFREE
Desmoplastic small round cell tumor is a recently described entity associated with fusion of the EWS and WT1 genes and with expression of a chimeric transcript.7495283 1995
×
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.400
GeneticVariation
disease
BEFREE
Southern hybridization showed that the Ewing sarcoma gene (EWS ) gene was rearranged in the DSRCT .
8522311 1995
×
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.400
Biomarker
disease
BEFREE
These assays detect PAX3-FKHR and PAX7-FKHR chimeric transcripts in alveolar rhabdomyosarcoma, EWS-FLI1 and EWS-ERG chimeric transcripts in Ewing's sarcoma, and EWS -WT1 chimeric transcripts in desmoplastic small round cell tumor .
7530783 1995
×
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.400
GeneticVariation
disease
BEFREE
One desmoplastic small round cell tumor was found to have a variant EWS -WT1 chimeric product that included exon 8 of EWS EWS-FLI-1 chimeric RNA was present in all Ewing's sarcoma/primitive neuroectodermal tumor and not identified in any other tumor types, including desmoplastic small round cell tumor .
7495283 1995
×
Entrez Id: 923
Gene Symbol: CD6
CD6
0.010
GeneticVariation
disease
BEFREE
Furthermore, six of the translocations, namely the t(11;22), t(21;22), and t(7;22) of Ewing's sarcoma, the t(12;22) of clear cell sarcoma, the t(12 ;16) of myxoid liposarcoma, and the t(11;22) of desmoplastic small round cell tumor , achieve this following a peculiar pattern, consisting in the fusion of a gene with an RNA-binding domain (EWS or TLS) with a transcription factor gene (FLI1, ERG, ETV1, ATF-1, CHOP, or WT1).
7493135 1995
×
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600
Biomarker
disease
BEFREE
Detection of the EWS/WT1 gene fusion by reverse transcriptase-polymerase chain reaction in the diagnosis of intra-abdominal desmoplastic small round cell tumor .
8604806 1996
×
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.400
Biomarker
disease
BEFREE
Due to the central role of the IGF-I-R in tumorigenesis, activation of the receptor promoter by EWS /WT1 may constitute a potential mechanism for the etiology and/or progression of DSRCT .
8702614 1996
×
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.020
AlteredExpression
disease
BEFREE
Due to the central role of the IGF-I-R in tumorigenesis, activation of the receptor promoter by EWS/WT1 may constitute a potential mechanism for the etiology and/or progression of DSRCT .
8702614 1996
×
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.400
GeneticVariation
disease
BEFREE
The potentially diagnostic chromosomal translocations and associated genes identified in STT include Ewing's/PNET t(11;22)(q24;q12) (FLI1;EWS ), t(21;22)(q22;q12) (ERG; EWS ); t(7;22)(p22;q12) (ETV1;EWS ); desmoplastic small round cell tumor t(11;22)(p13;q12) (WT1;EWS ); extraskeletal myxoid chondrosarcoma t(9;22)(q22;q12) (TEC(CHN);EWS ); malignant ectomesenchymoma t(11;22)(q24;q12) (FLI1;EWS ); alveolar rhabdomyosarcoma t(2;13)(q35;q14) (PAX-3;FKHR); t(1;13) (p36;q14)(PAX-7;FKHR); myxoid and round cell liposarcoma t(12;16)(q13;p11) (CHOP;TLS(FUS)); synovial sarcoma t(X;18)(p11;q11) (SSX1&2;SYT), and others.
9344317 1997
×
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.400
GeneticVariation
disease
BEFREE
A t(11;22)(p13;p12) chromosomal translocation, juxtaposing the Wilms' tumor (WT1) and Ewing's sarcoma (EWS ) genes, is the cytogenetic hallmark of desmoplastic small round cell tumor (DSRCT ), a primitive multiphenotypic sarcoma arising in serosal tissues.
9071577 1997
×
Entrez Id: 2313
Gene Symbol: FLI1
FLI1
0.040
GeneticVariation
disease
BEFREE
The potentially diagnostic chromosomal translocations and associated genes identified in STT include Ewing's/PNET t(11;22)(q24;q12) (FLI1 ;EWS), t(21;22)(q22;q12) (ERG; EWS); t(7;22)(p22;q12) (ETV1;EWS); desmoplastic small round cell tumor t(11;22)(p13;q12) (WT1;EWS); extraskeletal myxoid chondrosarcoma t(9;22)(q22;q12) (TEC(CHN);EWS); malignant ectomesenchymoma t(11;22)(q24;q12) (FLI1 ;EWS); alveolar rhabdomyosarcoma t(2;13)(q35;q14) (PAX-3;FKHR); t(1;13) (p36;q14)(PAX-7;FKHR); myxoid and round cell liposarcoma t(12;16)(q13;p11) (CHOP;TLS(FUS)); synovial sarcoma t(X;18)(p11;q11) (SSX1&2;SYT), and others.
9344317 1997
×
Entrez Id: 5077
Gene Symbol: PAX3
PAX3
0.020
GeneticVariation
disease
BEFREE
The potentially diagnostic chromosomal translocations and associated genes identified in STT include Ewing's/PNET t(11;22)(q24;q12) (FLI1;EWS), t(21;22)(q22;q12) (ERG; EWS); t(7;22)(p22;q12) (ETV1;EWS); desmoplastic small round cell tumor t(11;22)(p13;q12) (WT1;EWS); extraskeletal myxoid chondrosarcoma t(9;22)(q22;q12) (TEC(CHN);EWS); malignant ectomesenchymoma t(11;22)(q24;q12) (FLI1;EWS); alveolar rhabdomyosarcoma t(2;13)(q35;q14) (PAX-3 ;FKHR); t(1;13) (p36;q14)(PAX-7;FKHR); myxoid and round cell liposarcoma t(12;16)(q13;p11) (CHOP;TLS(FUS)); synovial sarcoma t(X;18)(p11;q11) (SSX1&2;SYT), and others.
9344317 1997
×
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.020
GeneticVariation
disease
BEFREE
The potentially diagnostic chromosomal translocations and associated genes identified in STT include Ewing's/PNET t(11;22)(q24;q12) (FLI1;EWS), t(21;22)(q22;q12) (ERG; EWS); t(7;22)(p22;q12) (ETV1;EWS); desmoplastic small round cell tumor t(11;22)(p13;q12) (WT1;EWS); extraskeletal myxoid chondrosarcoma t(9;22)(q22;q12) (TEC(CHN);EWS); malignant ectomesenchymoma t(11;22)(q24;q12) (FLI1;EWS); alveolar rhabdomyosarcoma t(2;13)(q35;q14) (PAX-3;FKHR); t(1;13) (p36;q14)(PAX-7 ;FKHR); myxoid and round cell liposarcoma t(12;16)(q13;p11) (CHOP;TLS(FUS)); synovial sarcoma t(X;18)(p11;q11) (SSX1&2;SYT), and others.
9344317 1997
×
Entrez Id: 2078
Gene Symbol: ERG
ERG
0.020
GeneticVariation
disease
BEFREE
The potentially diagnostic chromosomal translocations and associated genes identified in STT include Ewing's/PNET t(11;22)(q24;q12) (FLI1;EWS), t(21;22)(q22;q12) (ERG ; EWS); t(7;22)(p22;q12) (ETV1;EWS); desmoplastic small round cell tumor t(11;22)(p13;q12) (WT1;EWS); extraskeletal myxoid chondrosarcoma t(9;22)(q22;q12) (TEC(CHN);EWS); malignant ectomesenchymoma t(11;22)(q24;q12) (FLI1;EWS); alveolar rhabdomyosarcoma t(2;13)(q35;q14) (PAX-3;FKHR); t(1;13) (p36;q14)(PAX-7;FKHR); myxoid and round cell liposarcoma t(12;16)(q13;p11) (CHOP;TLS(FUS)); synovial sarcoma t(X;18)(p11;q11) (SSX1&2;SYT), and others.
9344317 1997
×
Entrez Id: 6857
Gene Symbol: SYT1
SYT1
0.020
GeneticVariation
disease
BEFREE
The potentially diagnostic chromosomal translocations and associated genes identified in STT include Ewing's/PNET t(11;22)(q24;q12) (FLI1;EWS), t(21;22)(q22;q12) (ERG; EWS); t(7;22)(p22;q12) (ETV1;EWS); desmoplastic small round cell tumor t(11;22)(p13;q12) (WT1;EWS); extraskeletal myxoid chondrosarcoma t(9;22)(q22;q12) (TEC(CHN);EWS); malignant ectomesenchymoma t(11;22)(q24;q12) (FLI1;EWS); alveolar rhabdomyosarcoma t(2;13)(q35;q14) (PAX-3;FKHR); t(1;13) (p36;q14)(PAX-7;FKHR); myxoid and round cell liposarcoma t(12;16)(q13;p11) (CHOP;TLS(FUS)); synovial sarcoma t(X;18)(p11;q11) (SSX1&2;SYT ), and others.
9344317 1997
×
Entrez Id: 6760
Gene Symbol: SS18
SS18
0.020
GeneticVariation
disease
BEFREE
The potentially diagnostic chromosomal translocations and associated genes identified in STT include Ewing's/PNET t(11;22)(q24;q12) (FLI1;EWS), t(21;22)(q22;q12) (ERG; EWS); t(7;22)(p22;q12) (ETV1;EWS); desmoplastic small round cell tumor t(11;22)(p13;q12) (WT1;EWS); extraskeletal myxoid chondrosarcoma t(9;22)(q22;q12) (TEC(CHN);EWS); malignant ectomesenchymoma t(11;22)(q24;q12) (FLI1;EWS); alveolar rhabdomyosarcoma t(2;13)(q35;q14) (PAX-3;FKHR); t(1;13) (p36;q14)(PAX-7;FKHR); myxoid and round cell liposarcoma t(12;16)(q13;p11) (CHOP;TLS(FUS)); synovial sarcoma t(X;18)(p11;q11) (SSX1&2;SYT ), and others.
9344317 1997
×
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.020
GeneticVariation
disease
BEFREE
The potentially diagnostic chromosomal translocations and associated genes identified in STT include Ewing's/PNET t(11;22)(q24;q12) (FLI1;EWS), t(21;22)(q22;q12) (ERG; EWS); t(7;22)(p22;q12) (ETV1;EWS); desmoplastic small round cell tumor t(11;22)(p13;q12) (WT1;EWS); extraskeletal myxoid chondrosarcoma t(9;22)(q22;q12) (TEC(CHN);EWS); malignant ectomesenchymoma t(11;22)(q24;q12) (FLI1;EWS); alveolar rhabdomyosarcoma t(2;13)(q35;q14) (PAX-3;FKHR ); t(1;13) (p36;q14)(PAX-7;FKHR ); myxoid and round cell liposarcoma t(12;16)(q13;p11) (CHOP;TLS(FUS)); synovial sarcoma t(X;18)(p11;q11) (SSX1&2;SYT), and others.
9344317 1997