Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4771
Gene Symbol: NF2
NF2
0.330 PosttranslationalModification disease BEFREE The role and regulatory mechanism of IL-1β on the methylation of the NF2 gene in benign meningiomas and leptomeninges. 26840621 2016
Entrez Id: 4771
Gene Symbol: NF2
NF2
0.330 Biomarker disease CTD_human Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. 23334667 2013
Entrez Id: 4771
Gene Symbol: NF2
NF2
0.330 GeneticVariation disease BEFREE Results showed a high frequency of NF2 gene mutations (40%), increased 22q LOH as aggressiveness increased, frequent losses and gains by MLPA in benign meningiomas, and gene expression silencing by hypermethylation. 19148485 2009
Entrez Id: 4771
Gene Symbol: NF2
NF2
0.330 Biomarker disease BEFREE The neurofibromatosis Type 2 (NF2) gene is the only tumor suppressor gene that has been clearly implicated in the development of benign meningiomas. 11147878 2001
Entrez Id: 1471
Gene Symbol: CST3
CST3
0.310 Biomarker disease CTD_human Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors. 19747051 2010
Entrez Id: 1476
Gene Symbol: CSTB
CSTB
0.310 Biomarker disease CTD_human Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors. 19747051 2010
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.310 Biomarker disease CTD_human Regression of multiple intracranial meningiomas after cessation of long-term progesterone agonist therapy. 19731987 2010
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.310 Biomarker disease CTD_human Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors. 19747051 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.310 Biomarker disease BEFREE These results suggest that the tumor suppressors p53/p21 signaling pathway and PTEN play important roles in the development of benign meningiomas. 17245624 2007
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.310 Biomarker disease BEFREE The immunoprofile was similar to normal cap cells with one exception; whereas normal cells were uniformly negative for PR, nuclear positivity was seen in 64% of hyperplasias, a frequency similar to that of benign meningiomas. 15912882 2005
Entrez Id: 1471
Gene Symbol: CST3
CST3
0.310 AlteredExpression disease BEFREE Protein and mRNA levels of stefin B (p= 0.007), but not cystatin C, were significantly lower in atypical compared with benign meningiomas. 15832773 2005
Entrez Id: 1476
Gene Symbol: CSTB
CSTB
0.310 AlteredExpression disease BEFREE Protein and mRNA levels of stefin B (p= 0.007), but not cystatin C, were significantly lower in atypical compared with benign meningiomas. 15832773 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.310 Biomarker disease CTD_human The reported patient, in addition to glioma, had suffered from benign meningioma in the past but did not show any clinical signs of Cowden disease or other hereditary diseases typically associated with PTEN germline mutations. 12085208 2002
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.310 Biomarker disease CTD_human Sphenoid wing meningioma progression after placement of a subcutaneous progesterone agonist contraceptive implant. 8008172 1994
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
0.300 Biomarker disease CTD_human Inference on germline BAP1 mutations and asbestos exposure from the analysis of familial and sporadic mesothelioma in a high-risk area. 25231345 2015
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.300 Biomarker disease CTD_human Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. 23334667 2013
Entrez Id: 6608
Gene Symbol: SMO
SMO
0.300 Biomarker disease CTD_human Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. 23334667 2013
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10
0.300 Biomarker disease CTD_human Common variation at 10p12.31 near MLLT10 influences meningioma risk. 21804547 2011
Entrez Id: 1514
Gene Symbol: CTSL
CTSL
0.300 Biomarker disease CTD_human Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors. 19747051 2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
0.300 Biomarker disease CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729 2010
Entrez Id: 210
Gene Symbol: ALAD
ALAD
0.300 Biomarker disease CTD_human Delta-aminolevulinic acid dehydratase polymorphism and risk of brain tumors in adults. 16140629 2005
Entrez Id: 4288
Gene Symbol: MKI67
MKI67
0.020 GeneticVariation disease BEFREE Association of high MIB-1 LI with 14q deletions, even in meningiomas with a Grade I histology, defines a distinct subset of benign meningiomas. 27841196 2018
Entrez Id: 4288
Gene Symbol: MKI67
MKI67
0.020 Biomarker disease BEFREE We also compared the average change in expression level of the three genes (CCNB1, CDC2, and MKI67) in atypical/anaplastic versus benign meningiomas; the difference between the groups was highly significant (P<0.001). 22137483 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.020 GeneticVariation disease BEFREE In order to investigate the disruption of the p53 function in a patient presenting this mutation and the TP53Arg72Pro polymorphism who had so far suffered five malignant tumors and a benign meningioma, we tested her fibroblasts in response to DNA damage by evaluating the proliferation rate, apoptosis, and disruption of the TP53 pathway. 20198344 2010
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.020 AlteredExpression disease BEFREE C-Myc mRNA and protein levels were not grade-related, but validated subdivision of the 36 benign meningiomas into two groups, Groups IA and IB, based on histological and clinical features (Ki-67-proliferative index, absence or presence of mitoses, rate of recurrence and incidence of perilesional edema). 18808065 2008