Gene: HOTAIR ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 Biomarker disease BEFREE Together, our results revealed an important role of HOTAIR in regulating cervical cancer resistance to radiotherapy. 30367473 2019
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 Biomarker disease BEFREE HOTAIR and TET1 are involved in modulation of the Wnt/β-catenin signaling pathway, but their role in cervical cancer remains to be elucidated. 31820855 2019
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 Biomarker disease BEFREE Taken together, our study has identified a novel pathway through which HOTAIR exerts its oncogenic role, and provided a molecular basis for potential applications of HOTAIR in the prognosis and treatment of cervical cancer. 29335299 2018
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 Biomarker disease BEFREE However, the role of HOTAIR in human cervical cancer is still unclear. 29572071 2018
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 Biomarker disease BEFREE However, the function of HOTAIR on radioresistance involving the regulation of HIF-1α in cervical cancer has not been reported. 30355300 2018
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 Biomarker disease BEFREE We therefore designed this study to investigate the clinical roles of lncRNAs HOTAIR SNPs in cervical cancer. 30275757 2018
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 Biomarker disease BEFREE ARFHPV E7 oncogene, lncRNA HOTAIR, miR-331-3p and its target, NRP2, form a negative feedback loop to regulate the apoptosis in the tumorigenesis in HPV positive cervical cancer. 29130509 2018
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 Biomarker disease BEFREE Tissue microarray and immunohistochemical staining were used to assess the correlation between HOTAIR and MKL1 in Cervical cancer tissues in vivo. 29391067 2018
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 Biomarker disease BEFREE Whereas, the potential molecular mechanism of HOTAIR involved in cervical cancer progression is still needed to be elaborated. 29336659 2018
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 Biomarker disease BEFREE In our present study, we aimed to explore the regulating role of HOTAIR in the progression of cervical cancer. 28893349 2017
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 GeneticVariation disease BEFREE TCGA database showed the CC tissues with rs7958904 CC genotype had higher HOTAIR expression than those with GG genotype (P = 0.046). 28600545 2017
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 AlteredExpression disease BEFREE High HOTAIR expression was associated with shorter overall survival in cervical cancer (HR = 3.93, 95% CI = 2.34-6.62, <i>P</i> < 0.001, fixed-effect). 28977961 2017
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 GeneticVariation disease BEFREE Furthermore, HOTAIR expression was higher in cervical cancer tissues than that in corresponding normal tissues, and the high expression was associated with the risk-associated allele T. In summary, our studies provide strong functional evidence that functional SNP rs920778 regulates HOTAIR expression, and may ultimately influence the predisposition for cervical cancer. 27467165 2016
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 AlteredExpression disease BEFREE Downregulation of HOTAIR Expression Mediated Anti-Metastatic Effect of Artesunate on Cervical Cancer by Inhibiting COX-2 Expression. 27736969 2016
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 GeneticVariation disease BEFREE In conclusion, we firstly reported that TT genotype of HOTAIR rs920778 was significantly associated with the cervical cancer susceptibility. 27229487 2016
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 AlteredExpression disease BEFREE Compared with control patients, HOTAIR expression was significantly greater in the serum of cervical cancer patients (P < 0.001). 27323817 2016
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 AlteredExpression disease BEFREE We found that miR-22 expression negatively correlated with HOTAIR and E7 expression in HPV16 positive cases and in an E7 transfected HPV negative CaCx-derived cell line (C33A), but was not altered in high HOTAIR cases compared to controls. 27683269 2016
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 AlteredExpression disease BEFREE Long non-coding RNA HOTAIR modulates HLA-G expression by absorbing miR-148a in human cervical cancer. 27574106 2016
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 Biomarker disease BEFREE Knockdown of HOTAIR reduced cell proliferation, migration, and invasion in cervical cancer cell lines. 25405331 2015
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.100 Biomarker disease BEFREE However, whether HOTAIR could serve as novel biomarker to predict prognosis in cervical cancer or not is unknown. 24748337 2014