This study is aiming to study the relationship among SMAD3, long noncoding RNAs (lncRNAs) OPA-interacting protein 5 antisense transcript 1 (OIP5-AS1), and miR-143-3p, and their effects on cervical cancer.
These results suggest that MSI-2 plays a crucial role in promoting the aggressive phenotypes of CC cells, and restoration of miR-143/miR-107 by Mithramycin A via activation of p53 may represent a novel therapeutic approach for CC.
The present study aimed to investigate the effect of ALA‑PDT on human cervical cancer through the regulation of microRNA‑143 (miR‑143) and the Bcl-2/Bax signaling pathway.
Direct involvement in the regulation of Bcl-2 may be one of the mechanisms through which miR-143 may play a role in the pathogenesis of cervical cancer.
These observations were in stark contrast to previous reports involving cervical cancer cell lines in which mir-143 was consistently down-regulated but mir-21 largely unaffected.