Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.040 Biomarker disease BEFREE Besides its responsiveness, the promoter strength proved sufficient for generating therapeutically efficacious levels interleukin-4, as demonstrated by the successful protection against cartilage erosion in collagen-induced arthritis. 17851546 2007
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.040 GeneticVariation disease BEFREE On a cellular level, the V50 allele conferred significantly reduced responsiveness to interleukin-4, providing a possible mechanism for the association of the I50V IL4R polymorphism with early erosions in RA. 16646030 2006
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.040 AlteredExpression disease BEFREE The reports on the anti-inflammatory effect of AdIL-4 are conflicting; however, all present data showed that IL-4 overexpression provides impressive protection against cartilage and bone erosion. 11840694 2002
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.040 AlteredExpression disease BEFREE Although severe inflammation persisted in treated mice, Ad5E1mIL-4 prevented bone erosion and diminished tartrate-resistant acid phosphatase (TRAP) activity, indicating that local IL-4 inhibits the formation of osteoclast-like cells. 10862785 2000