| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Interleukin 17 (IL-17) is a pro-inflammatory cytokine mainly produced by T helper 17 (Th17) cells which cause tissue inflammation and bone erosion leading to joint destruction. | 29543869 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | The unified effect of IL-17 and CoCl<sub>2</sub> markedly increased osteoclast mediated bone erosion through the activation of RANKL/NF-κB/NFATc1 signaling pathway. | 30029761 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We review the various osteoimmune pathologies, including the bone destruction in RA, in which pathogenic helper T cell subsets [such as IL-17-expressing helper T (Th17) cells] induce bone erosion through aberrant RANKL expression. | 28814613 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | In LVSmad7-injected joints, there were lower arthritis and histological scores with less synovitis, synovial hyperplasia and erosion on cartilage and bone as well as reduced IL-17 and TNF expression levels in comparison with other control groups. | 27731365 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | The histological appearance of joint inflammation (cellular inflammation and bone erosion) is similar in the i.p. versus s.c. immunized mice despite the presence of CD4(+) T cells producing IL-17 in joint tissues only after s.c. immunization. | 23630349 | 2013 | ||||
|
0.080 | Biomarker | disease | BEFREE | Histological analysis showed increased pannus formation associated with cartilage and bone erosion following injection with IL-17. | 22825627 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | IL-17 is also implicated in bone destruction in autoimmune arthritis, however, histological analysis of the arthritic joints from WT and IL-17-/- mice revealed a similar extent of joint cellularity, cartilage destruction, and bone erosion despite significantly reduced RANKL (receptor activator of NK-kappaB ligand) expression. | 18566398 | 2008 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | These findings suggest T cell IL-17 to be an important inducer of RANKL expression leading to loss of the RANKL/OPG balance, stimulating osteoclastogenesis and bone erosion in arthritis. | 12594294 | 2003 |