<i>In vivo</i> delivery of miR-146a to Ly6C<sup>high</sup> monocytes, and not to Ly6C<sup>low</sup> monocytes, rescues bone erosion in miR-146a<sup>-/-</sup> arthritic mice and reduces osteoclast differentiation and pathogenic bone erosion in CIA joints of miR-146a<sup>+/+</sup> mice, with no effect on inflammation.
We investigated the role of IRAK1 single-nucleotide polymorphism (SNP) rs3027898 (IRAK1 rs3027898) and miR-146a SNP rs2910164 (miR-146ars2910164) in Tunisian patients with RA and their association with C reactive protein (CRP), rheumatoid factor (RF), anticyclic citrullinated peptide (anti-CCP) antibodies, and erosion.