×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.200
Biomarker
disease
HPO
×
Entrez Id:
4137
Gene Symbol:
MAPT
MAPT
0.200
Biomarker
disease
HPO
×
Entrez Id:
5621
Gene Symbol:
PRNP
PRNP
0.200
Biomarker
disease
HPO
×
Entrez Id:
5663
Gene Symbol:
PSEN1
PSEN1
0.200
Biomarker
disease
HPO
×
Entrez Id:
54209
Gene Symbol:
TREM2
TREM2
0.130
Biomarker
disease
HPO
×
Entrez Id:
5664
Gene Symbol:
PSEN2
PSEN2
0.120
Biomarker
disease
HPO
×
Entrez Id:
10347
Gene Symbol:
ABCA7
ABCA7
0.110
Biomarker
disease
HPO
×
Entrez Id:
2896
Gene Symbol:
GRN
GRN
0.110
Biomarker
disease
HPO
×
Entrez Id:
25978
Gene Symbol:
CHMP2B
CHMP2B
0.100
Biomarker
disease
HPO
×
Entrez Id:
7415
Gene Symbol:
VCP
VCP
0.100
Biomarker
disease
HPO
×
Entrez Id:
203228
Gene Symbol:
C9orf72
C9orf72
0.100
Biomarker
disease
HPO
TMEM106B
0.100
Biomarker
disease
HPO
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
0.020
Biomarker
disease
BEFREE
Indeed, it is likely that prealbumin is the major constituent of amyloid associated with neuritic plaque , neurofibrillary tangle, and microangiopathy.
6950666
1982
×
Entrez Id:
2670
Gene Symbol:
GFAP
GFAP
0.070
AlteredExpression
disease
BEFREE
In AD, the latter pattern predominates, consistent with induction of GFAP mRNA in the sites of synthesis in glial processes in the neuritic plaque .
3507557
1987
×
Entrez Id:
351
Gene Symbol:
APP
APP
0.400
Biomarker
disease
BEFREE
Unexpectedly, the antibodies to the carboxyl terminus of beta APP labeled amyloid-containing senile plaques in AD brain.
3140239
1988
×
Entrez Id:
351
Gene Symbol:
APP
APP
0.400
Biomarker
disease
BEFREE
The regulation of extracellular proteolysis by PN-II and the deposition of at least parts of the molecule in senile plaques is consistent with previous reports that implicate altered proteolysis in the pathogenesis of Alzheimer's disease.
2507928
1989
×
Entrez Id:
351
Gene Symbol:
APP
APP
0.400
Biomarker
disease
BEFREE
The beta-amyloid protein (beta/A4), derived from a larger amyloid precursor protein (APP ), is the principal component of senile plaques in Alzheimer's disease.
1691865
1990
×
Entrez Id:
351
Gene Symbol:
APP
APP
0.400
Biomarker
disease
BEFREE
The beta-amyloid peptide is a core component of the neuritic plaques that accumulate in Alzheimer's disease.
2115911
1990
×
Entrez Id:
5621
Gene Symbol:
PRNP
PRNP
0.200
Biomarker
disease
BEFREE
Some transgenic (Tg) mouse (Mo) lines that carry and express a Syrian hamster (Ha) PrP gene developed scrapie 75 d after inoculation with Ha prions; non-Tg mice failed to show symptoms after greater than 500 d. Brains of these infected Tg(HaPrP) mice featured protease-resistant HaPrPSc, amyloid plaques characteristic for Ha scrapie, and 10(9) ID50 units of Ha-specific prions upon bioassay.
1684745
1991
×
Entrez Id:
351
Gene Symbol:
APP
APP
0.400
Biomarker
disease
BEFREE
It is known that beta APP accumulates in the neuritic plaques and cerebrovascular deposits of patients with Alzheimer's disease.
1593645
1992
×
Entrez Id:
351
Gene Symbol:
APP
APP
0.400
Biomarker
disease
BEFREE
Apolipoprotein E (APO-E) binds to the beta-amyloid peptide and is present in senile neuritic plaques in Alzheimer's disease (AD).
8239575
1993
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.200
Biomarker
disease
BEFREE
Apolipoprotein E (apoE ) is associated with Alzheimer's neurofibrillary tangles and beta-amyloid protein in senile plaques .
8103819
1993
×
Entrez Id:
5621
Gene Symbol:
PRNP
PRNP
0.200
Biomarker
disease
BEFREE
Neuritic plaques characteristic of AD were once thought to be exclusively associated with beta-A4 amyloid; however, some pedigrees with familial prion disease produced neuritic plaques with PrP amyloid cores.
7904883
1993
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.200
Biomarker
disease
BEFREE
In vitro, apolipoprotein E in cerebrospinal fluid binds to synthetic beta A4 peptide (the primary constituent of the senile plaque ) with high avidity.
8446617
1993
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.200
Biomarker
disease
BEFREE
Apolipoprotein E (APO-E ) binds to the beta-amyloid peptide and is present in senile neuritic plaques in Alzheimer's disease (AD).
8239575
1993