Inhibition of p38 MAPK in the present study protected SH-SY5Y cells from the toxicity of Aβ<sub>1-42</sub>, and alleviated the formation of senile plaques and cognitive impairment in AD mice.
Strong active SAPK/JNK and p38 immunoreactivity has been observed restricted to neurons and glial cells containing hyperphosphorylated tau, as well as in dystrophic neurites of senile plaques in AD.
Strong active SAPK/JNK and p38 immunoreactivity has been observed restricted to neurons and glial cells containing hyperphosphorylated tau, as well as in dystrophic neurites of senile plaques in AD.