Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 Biomarker phenotype BEFREE Diffuse strong parabasal immunostaining for p16(INK4a), suggestive of integrated high-risk HPV DNA into the host genome, was observed in 81 biopsies (42.9%, including the cervical polyp) and correlated (>90%) with HGSIL in the H&E sections. 16028838 2005
Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
0.100 Biomarker phenotype BEFREE The Lower Anogenital Squamous Terminology (LAST) Standardization Project for human papilloma virus (HPV)-associated lesions specifically recommends the use of p16 immunohistochemistry (IHC) as an adjunct to morphologic assessment of cervical biopsies interpreted as negative or low-grade squamous intraepithelial lesion (LSIL) from patients with prior high-risk Pap test results (high-grade squamous intraepithelial lesion [HSIL], atypical squamous cells cannot exclude HSIL, atypical glandular cells [AGC], or HPV16 atypical squamous cells of undetermined significance [ASC-US]). 29112019 2018
Entrez Id: 412
Gene Symbol: STS
STS
0.100 Biomarker phenotype BEFREE There was no difference in the ability of LSIL-H and ASC-H to predict CIN 2+. 27245707 2017
Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
0.100 Biomarker phenotype BEFREE Positive scores for Ki-67, cyclin E, and p16 were seen in 68.4%, 96.7%, and 100% of LSILs and 94.7%, 91.6%, and 100% of HSILs, respectively. 11420459 2001
Entrez Id: 412
Gene Symbol: STS
STS
0.100 Biomarker phenotype BEFREE Positive rate of high-risk HPV DNA in groups of atypical squamous cells of undetermined significance (ASC-US), atypical squamous cells, cannot exclude high-grade (ASC-H), low-grade squamous intraepithelial lesions and high-grade squamous intraepithelial lesions was 53.7, 53.2, 84.6 and 93.0%, respectively. 17355305 2007
Entrez Id: 29108
Gene Symbol: PYCARD
PYCARD
0.100 Biomarker phenotype BEFREE Forty-five patients underwent conization for known lesions ranging from atypical squamous cells of undetermined significance (ASC-US) with high-risk HPV (hr-HPV) to high-grade squamous intraepithelial lesion (H-SIL/CIN2+) or adenocarcinoma. 19689463 2010
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 Biomarker phenotype BEFREE Immunohistochemical p16 staining was used to confirm lesions of thin HSIL. 27513079 2017
Entrez Id: 29108
Gene Symbol: PYCARD
PYCARD
0.100 Biomarker phenotype BEFREE Two women with ASC-US who were HPV DNA negative by the HC-II and positive by the TS-MPG or/and LA assays had lesions that progressed to low-grade squamous intraepithelial and high-grade squamous intraepithelial lesions. 23035194 2012
Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
0.100 AlteredExpression phenotype BEFREE One hundred seven cases, including 23 negative cases, 34 with low-grade squamous intraepithelial lesion (LSIL), 16 with high-grade squamous intraepithelial lesion (HSIL), 29 with atypical squamous cells of uncertain significance (ASC-US), and 5 cases with ASC suspicious for HSIL (ASC-H), were evaluated for both p16 expression and HPV DNA. 15584047 2005
Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
0.100 Biomarker phenotype BEFREE Immunohistochemical p16 staining was used to confirm lesions of thin HSIL. 27513079 2017
Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
0.100 Biomarker phenotype BEFREE We studied gene amplification and protein expression of ERBB2 and EGFR and their relationship with Ki67, p16 and p53 and HPV presence in 22 normal/benign (N/B) cervices, 20 low-grade squamous intraepithelial lesions (LSILs), 70 high-grade SILs (HSILs) and 32 invasive squamous cervical carcinomas (ISCCs). 23827764 2013
Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
0.100 Biomarker phenotype BEFREE Use of human papillomavirus DNA, E6/E7 mRNA, and p16 immunocytochemistry to detect and predict anal high-grade squamous intraepithelial lesions in HIV-positive and HIV-negative men who have sex with men. 24265682 2013
Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
0.100 Biomarker phenotype BEFREE Immunohistochemical expression of p16 may not be a predictor of HSIL risk in vulvar LSIL, although this result may also be related to the very low rates of both p16 positivity and subsequent vulvar HSIL in our sample. 28719486 2017
Entrez Id: 29108
Gene Symbol: PYCARD
PYCARD
0.100 Biomarker phenotype BEFREE Positive rate of high-risk HPV DNA in groups of atypical squamous cells of undetermined significance (ASC-US), atypical squamous cells, cannot exclude high-grade (ASC-H), low-grade squamous intraepithelial lesions and high-grade squamous intraepithelial lesions was 53.7, 53.2, 84.6 and 93.0%, respectively. 17355305 2007
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 AlteredExpression phenotype BEFREE The results showed that SOX2 expression was limited to the basal one third in 84% of LSIL cases, whereas 95% of HSIL showed SOX2 expression up to two third or full thickness (P<0.0001). p16 and Ki-67 displayed similar results. 27490766 2018
Entrez Id: 29108
Gene Symbol: PYCARD
PYCARD
0.100 Biomarker phenotype BEFREE Thirty six of them (37.9%) showed abnormal anal cytology as follows: atypical squamous cells of undetermined significance (ASC-US) in 19 (20.0%), atypical squamous cells but cannot exclude HSIL (ASC-H) in 1 (1.1%), low-grade squamous intraepithelial lesion (LSIL) in 15 (15.8%), and high-grade squamous intraepithelial lesion (HSIL) in 1 (1.1%). 22558293 2012
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 Biomarker phenotype BEFREE Moreover, RIPK4 may serve as a useful biomarker to distinguish HSIL from chronic cervicitis/LSIL, which are two different clinical types for therapeutic procedures, with a high sensitivity and specificity (85.1% and 86.6%, respectively) and the performance improved when combined with p16(INK4a). 26148476 2015
Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
0.100 Biomarker phenotype BEFREE This study evaluates the performance of different p16 clones as compared with E6H4 (CINtec) in detecting high-grade squamous intraepithelial lesion. 28863068 2018
Entrez Id: 412
Gene Symbol: STS
STS
0.100 GeneticVariation phenotype BEFREE Of the remaining 139 (52.3%) cases, 86 (62%) had follow-up Pap Tests, of which 57 (66.3%) were negative, 15 (17.4%) were ASC-US, 12 (15%) were low-grade squamous intraepithelial lesions, and 2 (2.3%) were high-grade squamous intraepithelial lesions; 53 (38.1%) were lost to follow-up. 17041955 2006
Entrez Id: 29108
Gene Symbol: PYCARD
PYCARD
0.100 Biomarker phenotype BEFREE Liquid-based cytology cases interpreted as high-grade squamous intraepithelial lesion (HSIL); low-grade squamous intraepithelial lesion (LSIL); atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H); and atypical squamous cells of undetermined significance (ASC-US) at Magee-Womens Hospital (Pittsburgh, Pennsylvania) were retrospectively identified for a 36-month period between July 1, 2005, and June 30, 2008, from women 50 years and older who also had hrHPV DNA test results. 20670132 2010
Entrez Id: 29108
Gene Symbol: PYCARD
PYCARD
0.100 Biomarker phenotype BEFREE HPV-positive rates were determined in cases of low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL), and follow-up rates of cervical intraepithelial neoplasia (CIN) were determined in HPV-positive and -negative cases of atypical squamous cells of unknown significance (ASC-US). 17091508 2006
Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
0.100 Biomarker phenotype BEFREE Human papillomavirus infection and p16 promoter methylation might be valuable surrogate markers of disease progression from ASC-US/LSIL to HSIL. 26335500 2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 AlteredExpression phenotype BEFREE The bizarre cells expressed p16 and p63 proteins but usually lacked mitotic activity and showed less Ki-67 labelling than adjacent conventional HSIL. 28666641 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 PosttranslationalModification phenotype BEFREE Methylation status of the p16 ink4a promoter was assessed by methylation-specific PCR in 87 cervical specimens comprising 29 low-grade (LSIL), 41 high-grade (HSIL) lesions, and 17 cervical cancers (CC). 30569945 2018
Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
0.100 AlteredExpression phenotype BEFREE The results showed that SOX2 expression was limited to the basal one third in 84% of LSIL cases, whereas 95% of HSIL showed SOX2 expression up to two third or full thickness (P<0.0001). p16 and Ki-67 displayed similar results. 27490766 2018