Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
0.100 GeneticVariation disease BEFREE Therefore, the pedigree was diagnosed as an FAP family with a novel APC germline mutation which had different gastric phenotypes depending on the status of HP infection. 31529234 2019
Entrez Id: 811
Gene Symbol: CALR
CALR
0.100 Biomarker disease BEFREE Neither a mucus cap nor CP-II meshed capillary vessels showed statistical significance in differentiating SSA/P from HP (P = 0.590 and 0.293, respectively). 30693669 2019
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE Neither a mucus cap nor CP-II meshed capillary vessels showed statistical significance in differentiating SSA/P from HP (P = 0.590 and 0.293, respectively). 30693669 2019
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE Because HP versus SSP is not very reproducible the predictors of SSA/P that we identified, including size, location, and synchronous lesions, can offer some additional help to endoscopists when determining surveillance intervals in patients with serrated polyps. 28723863 2018
Entrez Id: 811
Gene Symbol: CALR
CALR
0.100 Biomarker disease BEFREE Because HP versus SSP is not very reproducible the predictors of SSA/P that we identified, including size, location, and synchronous lesions, can offer some additional help to endoscopists when determining surveillance intervals in patients with serrated polyps. 28723863 2018
Entrez Id: 811
Gene Symbol: CALR
CALR
0.100 Biomarker disease BEFREE These associations applied similarly to HP (1.47, 1.44-1.50), TA (1.30, 1.27-1.32), and SSA/P (1.52, 1.46-1.58). 29147879 2018
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE For large serrated polyp, NBI in combination with CE had a better accuracy than NBI alone (91% vs 86%, P = 0.025) to distinguish SSA/P from HP. 28687028 2018
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE Compared with the lesions without cancer, the lesions with cancer exhibited a larger size (HP, TSA and SSA/P), a reddish appearance (SSA/P), a two-tier raised appearance (HP and SSA/P), a central depression (HP, TSA and SSA/P), the type V pit pattern (HP, TSA and SSA/P), and/or the type III capillary pattern (TSA and SSA/P). 29805602 2018
Entrez Id: 811
Gene Symbol: CALR
CALR
0.100 Biomarker disease BEFREE For large serrated polyp, NBI in combination with CE had a better accuracy than NBI alone (91% vs 86%, P = 0.025) to distinguish SSA/P from HP. 28687028 2018
Entrez Id: 811
Gene Symbol: CALR
CALR
0.100 Biomarker disease BEFREE Compared with the lesions without cancer, the lesions with cancer exhibited a larger size (HP, TSA and SSA/P), a reddish appearance (SSA/P), a two-tier raised appearance (HP and SSA/P), a central depression (HP, TSA and SSA/P), the type V pit pattern (HP, TSA and SSA/P), and/or the type III capillary pattern (TSA and SSA/P). 29805602 2018
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE These associations applied similarly to HP (1.47, 1.44-1.50), TA (1.30, 1.27-1.32), and SSA/P (1.52, 1.46-1.58). 29147879 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation disease BEFREE No measurement of methylation or BRAF mutations in polyps or normal mucosa and a lack of subclassification of hyperplastic polyps limited this study. 30346367 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE The expression of p53 was found to be significantly decreased, while K-ras was increased in tumor tissues of CRC compared with that in hyperplastic polyps and healthy controls. 29104470 2017
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE To determine whether an educational intervention that improved adenoma detection rate (ADR) could improve SSA/P detection rate after reclassification of previously termed "hyperplastic" polyps. 28444509 2017
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE By using colonoscopies in adults aged ≥50 years (4/09-12/14), we stratified endoscopists by high and low ADRs (<15%, 15%-<25%, 25%-<35%, ≥35%) to determine corresponding SDRs by using 2 SDR measures, for screening and surveillance colonoscopies separately: (1) Clinically significant SDR (CSSDR), meaning colonoscopies with any sessile serrated adenoma/polyp (SSA/P), traditional serrated adenoma (TSA), or hyperplastic polyp (HP) >1 cm anywhere in the colon or HP >5 mm in the proximal colon only divided by the total number of screening and surveillance colonoscopies, respectively. 28153571 2017
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.100 GeneticVariation disease BEFREE Serrated polyps (hyperplastic polyps, sessile or traditional serrated adenomas), which can arise in a sporadic or polyposis setting, predispose to colorectal cancer (CRC), especially those with microsatellite instability (MSI) due to MLH1 promoter methylation (MLH1<sup>me+</sup>). 27329244 2017
Entrez Id: 811
Gene Symbol: CALR
CALR
0.100 Biomarker disease BEFREE By using colonoscopies in adults aged ≥50 years (4/09-12/14), we stratified endoscopists by high and low ADRs (<15%, 15%-<25%, 25%-<35%, ≥35%) to determine corresponding SDRs by using 2 SDR measures, for screening and surveillance colonoscopies separately: (1) Clinically significant SDR (CSSDR), meaning colonoscopies with any sessile serrated adenoma/polyp (SSA/P), traditional serrated adenoma (TSA), or hyperplastic polyp (HP) >1 cm anywhere in the colon or HP >5 mm in the proximal colon only divided by the total number of screening and surveillance colonoscopies, respectively. 28153571 2017
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE Furthermore, the possibility has been raised that pathologists misclassify SSA/P as hyperplastic polyp. 27376251 2017
Entrez Id: 811
Gene Symbol: CALR
CALR
0.100 Biomarker disease BEFREE We performed immunohistochemistry for Ki67, p16INK4a, and WNT5A in human HPs (n=22), SSA/Ps (n=41), and TSAs (n=19). 28627675 2017
Entrez Id: 811
Gene Symbol: CALR
CALR
0.100 Biomarker disease BEFREE To determine whether an educational intervention that improved adenoma detection rate (ADR) could improve SSA/P detection rate after reclassification of previously termed "hyperplastic" polyps. 28444509 2017
Entrez Id: 811
Gene Symbol: CALR
CALR
0.100 Biomarker disease BEFREE Overall, the mucin and associated O-glycan based panel defined in the present study could aid in discriminating SSA/P from HP to devise better colon surveillance strategies. 27705923 2017
Entrez Id: 811
Gene Symbol: CALR
CALR
0.100 Biomarker disease BEFREE Furthermore, the possibility has been raised that pathologists misclassify SSA/P as hyperplastic polyp. 27376251 2017
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE Overall, the mucin and associated O-glycan based panel defined in the present study could aid in discriminating SSA/P from HP to devise better colon surveillance strategies. 27705923 2017
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE We performed immunohistochemistry for Ki67, p16INK4a, and WNT5A in human HPs (n=22), SSA/Ps (n=41), and TSAs (n=19). 28627675 2017
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE KRAS mutations were identified in 11 polyps (48%), in more than half of SSAs and of TSAs, and in none of the four HPs. 27020206 2016