| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | disease | BEFREE | We sought to create a transgenic mouse with Cre recombinase (Cre) expression limited to the epithelial cells of the large intestine and used this model to study colon cancer driven by adenomatosis polyposis coli (APC) gene inactivation. | 20663863 | 2010 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | The role of germline inactivation of the adenomatosis polyposis coli (APC) gene in hereditary colorectal cancer is well known, being the most important cause of familial adenomatosus polyposis (FAP) syndrome. | 18369740 | 2008 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Inactivating mutations in the adenomatosis polyposis coli (APC) gene, which encodes a carrier protein for beta-catenin, or stabilizing mutations in beta-catenin itself, frequently occur in human tumours. | 16342409 | 2005 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Progressive duodenal adenomatosis in a familial adenomatous polyposis pedigree with APC mutation at codon 1556. | 11852337 | 2002 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Truncating APC gene mutation proximal to exon 9 may contribute to the less frequent development of duodenal adenomatosis in FAP, but severity and progression of duodenal adenomatosis do not seem to be determined by APC gene mutation alone. | 11808944 | 2002 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Phenotype-genotype correlations in an extended family with adenomatosis coli and an unusual APC gene mutation. | 11711730 | 2001 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis. | 10646887 | 2000 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Germline mutations in the adenomatosis polyposis coli (APC) gene cause FAP and Gardner syndrome and have recently been associated also with the development of AFAP. | 11145293 | 2000 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Inherited mutations of the APC gene predispose carriers to multiple adenomatous polyps of the colon and rectum and to colorectal cancer. | 10598803 | 1999 |