Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4916
Gene Symbol: NTRK3
NTRK3
0.100 GeneticVariation disease BEFREE ETV6-NTRK3 fusion gene transcripts that result from t(12;15)(p13;q25), which is characteristic of congenital/infantile fibrosarcoma, were not demonstrated. 11107054 2000
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation disease BEFREE As in congenital fibrosarcoma (CFS), two Tel-ETV6/ TrkC-NTRK3 fusion transcripts different by a 42 bp insert in the TrkC kinase domain were expressed. 12650516 2003
Entrez Id: 4916
Gene Symbol: NTRK3
NTRK3
0.100 Biomarker disease BEFREE Remarkably, this entity is the only epithelial tumor of the breast with a balanced translocation, t(12;15), that creates an ETV6-NTRK3 gene fusion encoding chimeric tyrosine kinase also encountered in cellular mesoblastic nephroma and infantile fibrosarcoma. 19011601 2009
Entrez Id: 4916
Gene Symbol: NTRK3
NTRK3
0.100 Biomarker disease BEFREE A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. 9462753 1998
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE The E-26 transforming specific (ETS)-related gene TEL, also known as ETV6, is involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. 10377438 1999
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation disease BEFREE The ETV6-NTRK3 (TEL-TRKC) gene fusion was discovered by breakpoint analysis of the t(12;15)(p13;q25) translocation associated with congenital fibrosarcoma, a pediatric soft tissue malignancy. 15826836 2005
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation disease BEFREE Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. 10895816 2000
Entrez Id: 4916
Gene Symbol: NTRK3
NTRK3
0.100 GeneticVariation disease BEFREE Infantile fibrosarcoma (IFS) is a malignant neoplasm, arising in children younger than 2 years of age and with a hallmark chromosomal translocation t(12;15)(p13;q26) encoding an ETV6-NTRK3 fusion oncoprotein. 24276045 2014
Entrez Id: 4916
Gene Symbol: NTRK3
NTRK3
0.100 Biomarker disease BEFREE Recurrent EML4-NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy. 29099503 2018
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE The ETV6-NTRK3 (EN) fusion has been implicated in various cancers, including infantile fibrosarcoma, secretory breast carcinoma, and acute myeloblastic leukemia, and has exhibited in vivo and in vitro transforming ability. 29391602 2018
Entrez Id: 4916
Gene Symbol: NTRK3
NTRK3
0.100 GeneticVariation disease BEFREE Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia. 10775267 2000
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation disease BEFREE Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia. 10775267 2000
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation disease BEFREE Remarkably, this entity is the only epithelial tumor of the breast with a balanced translocation, t(12;15), that creates an ETV6-NTRK3 gene fusion encoding chimeric tyrosine kinase also encountered in cellular mesoblastic nephroma and infantile fibrosarcoma. 19011601 2009
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE In two exceptional instances, the same translocation and gene fusion occurs in two unrelated diseases: ETV6-NTRK fusion in infantile fibrosarcoma and secretory carcinoma of the breast, and ALK-TPM3 fusion in inflammatory myofibroblastic tumor and large cell anaplastic lymphoma. 17163160 2006
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. 9462753 1998
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE Infantile fibrosarcoma is characterised by intersecting fascicles of spindle cells and ETV6-NTRK3 gene fusion in most cases. 29863809 2018
Entrez Id: 4916
Gene Symbol: NTRK3
NTRK3
0.100 Biomarker disease BEFREE Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors. 10658907 2000
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors. 10658907 2000
Entrez Id: 4916
Gene Symbol: NTRK3
NTRK3
0.100 GeneticVariation disease BEFREE The cellular variant of congenital mesoblastic nephroma (but not the classic variant) has been shown to bear the same t(12;15)(p13;q25) and ETV6-NTRK3 gene fusion as infantile fibrosarcoma, a tumor with which it shares morphologic and clinical features. 12973047 2003
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.030 Biomarker disease BEFREE The purpose of this study was to evaluate the potential diagnostic utility of pan-TRK immunohistochemistry for infantile fibrosarcoma. 29863809 2018
Entrez Id: 7170
Gene Symbol: TPM3
TPM3
0.030 Biomarker disease BEFREE The purpose of this study was to evaluate the potential diagnostic utility of pan-TRK immunohistochemistry for infantile fibrosarcoma. 29863809 2018
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.030 GeneticVariation disease BEFREE Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). 30220707 2018
Entrez Id: 7170
Gene Symbol: TPM3
TPM3
0.030 GeneticVariation disease BEFREE Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). 30220707 2018
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.030 Biomarker disease BEFREE Among enrolled patients harbouring TRK fusion-positive cancers, eight (47%) had infantile fibrosarcoma, seven (41%) had other soft tissue sarcomas, and two (12%) had papillary thyroid cancer. 29606586 2018
Entrez Id: 7170
Gene Symbol: TPM3
TPM3
0.030 Biomarker disease BEFREE Among enrolled patients harbouring TRK fusion-positive cancers, eight (47%) had infantile fibrosarcoma, seven (41%) had other soft tissue sarcomas, and two (12%) had papillary thyroid cancer. 29606586 2018