Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression disease BEFREE In addition, we found that high p53 expression levels and a nuclear survivin localization correlated with the AA subtype, whereas cytoplasmic survivin localization correlated with the GB subtype. 29374392 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Manganese superoxide dismutase (MnSOD) is a malignant astrocytoma specific biomarker and associated with adverse prognosis in p53 expressing glioblastoma. 26616112 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE This is the first report of the detection of an identical IDH2 mutation in multiple tissues and TP53 mutation in anaplastic astrocytoma in a patient with Maffucci syndrome. 24344754 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Both types of alterations were present in all analyzed samples contributing almost equally to the total level of genomic instability, and showing no differences between histological subtypes. p53 alterations were detected in 40% of samples, predominantly in anaplastic astrocytoma. 22664273 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE The lack of expression of GFAP or MAP-2 raised the question of a secondary malignancy, however, molecular genetic analysis of IDH1 and p53 revealed the same mutations in the anaplastic astrocytoma from 2006 as in the sarcomatoid tumor operated in 2010. 21955926 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Neural stem/progenitor cell (NPC)-specific constitutive Ras activation in vivo plus p53 deficiency led to development of primarily anaplastic astrocytoma (grade III), whereas combined loss of p53 plus p16(Ink4a)/p19(Arf) led to development of GBM (grade IV) at 100% penetrance within 6 weeks. 21169405 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE However, there is only anecdotal information about MGMT methylation status and TP53 mutations during progression of low-grade diffuse astrocytoma (AII) to anaplastic astrocytoma (AIII) and secondary glioblastoma (sGB). 20593220 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE TP53 mutations were detected in five of 27 (18%) cases (four glioblastomas and one anaplastic astrocytoma). 20174854 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Acute lymphoblastic leukemia after temozolomide treatment for anaplastic astrocytoma in a child with a germline TP53 mutation. 20658636 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression disease BEFREE To elucidate the relationship between p53 abnormality and invasiveness of the tumors, we studied mutation and protein expression of p53 in 48 consecutive patients with malignant astrocytoma (14 anaplastic astrocytomas and 34 glioblastoma multiformes). 21046311 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease CTD_mouse Bioluminescent approaches for measuring tumor growth in a mouse model of neurofibromatosis. 20176786 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Secondary glioblastomas that developed through progression from low-grade or anaplastic astrocytoma had TP53 mutations in 16 (84%) of 19 cases, but none contained mutations of the NBS1 gene. 19151620 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression disease BEFREE Low caveolin-1 expression correlated with a higher Ki-67 labeling index and the absence of p53 overexpression in glioblastomas, and it was significantly associated with epidermal growth factor receptor overexpression in anaplastic astrocytomas. 19716156 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Concurrent sequence variation of TP53 and TP73 genes in anaplastic astrocytoma. 19876867 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Coexistence of p53 gene mutations and the locus of heterozygosity was common, at least in astrocytomas grade III and in glioblastomas, and also occurred in astrocytoma grade II areas. 17917588 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE We examined TP53 status in relation to telomere maintenance mechanism (TMM) in 108 patients with glioblastoma multiforme and two patients with anaplastic astrocytoma from New Zealand and United Kingdom. 16818615 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE The apoptotic index (AI) was greater in GBM than in AA or DA, and more in tumours with p53 immunopositivity than in those without. 15981097 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 PosttranslationalModification disease BEFREE We analyzed the MGMT promoter methylation and TP53 mutations in 45 malignant astrocytomas (16 anaplastic astrocytomas and 29 glioblastomas multiforme) treated prospectively with 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-2(2-chloroethyl)-3-nitrosourea, interferon-beta and radiation therapy, and evaluated their clinical usefulness. 15455376 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression disease BEFREE There was a positive correlation of VEGF with p53 expression in astrocytomas and anaplastic astrocytomas. 15175080 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE We had previously reported that loss of heterozygosity (LOH) of the D17S379 locus on 17p13.3 was significantly more frequent in high-grade gliomas (anaplastic astrocytoma, AA; glioblastoma multiforme, GBM) than in those of a low-grade diffuse astrocytoma (DA); however, this was independent of alterations at the TP53 locus, We also showed that LOH of D17S379 was associated with positive staining for p53 protein on immunohistochemistry, but LOH of the TP53 gene had no such association. 12850379 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE LOH on 9p and/or CDKN2A deletion occurred more often in glioblastomas (P < 0.001), LOH on 17p/TP53 mutations occurred more frequently in anaplastic astrocytomas (AAs; P = 0.112), and LOH on 10q/PTEN mutation frequency was similar in glioblastomas and AAs (P < 0.001). 12173338 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE The incidence of p53 mutations was higher in anaplastic astrocytomas (AA, 48%) than glioblastomas (GBM, 31%). 12124823 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression disease BEFREE No SSCP alterations were observed in any of the p53 fragments amplified from WHO grade I pilocytic astrocytomas and WHO grade III anaplastic astrocytomas. 11724349 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Univariate survival analyses of patients with anaplastic astrocytoma identified PTEN (P =.002) and p53 (P =.012) mutations as statistically significantly associated with reduced and prolonged survival, respectively. 11504770 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Of 13 anaplastic astrocytomas with an altered RB1 pathway, 9 (69%) also showed a dysregulated TP53 pathway. 11764090 2001