Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.080 GeneticVariation disease BEFREE We present the case of a 28-year-old man with an IDH1 and TP53 mutant high grade glioma with abnormalities in chromosomes 1 and 19 suggestive of anaplastic oligodendroglioma that rapidly progressed to widespread metastatic disease. 30738431 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.080 GeneticVariation disease BEFREE We find evidence of regional mutational heterogeneity in multiple tumors, including mutations in TP53 and RB1 in an anaplastic oligodendroglioma and amplifications in PDGFRA and KIT in two glioblastomas (GBMs). 25608559 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.080 PosttranslationalModification disease BEFREE In addition, in patients with both IDH1 mutation and MGMT methylation, p53 overexpression was a significant poor prognostic factor both in LOs and AOs. 22922798 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.080 AlteredExpression disease BEFREE The expression of p53 protein was more frequently observed in patients without a 1p or 19q deletion in anaplastic oligodendrogliomas (P = 0.032, 0.025). 22166632 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.080 AlteredExpression disease BEFREE The expressions of p53 and GFAP were more frequent in AO than in LO (P= 0.015 and 0.001). 17319279 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.080 GeneticVariation disease BEFREE In this study, we screened 28 oligodendrogliomas (WHO grade II) and 20 anaplastic oligodendrogliomas (WHO grade III) for alterations in the RB1/CDK4/p16INK4a/p15INK4b and TP53/p14ARF/MDM2 pathways. 11764090 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.080 GeneticVariation disease BEFREE These findings demonstrate that oligodendroglial neoplasms usually have loss of 1p and 19q whereas astrocytomas of the progressive type frequently contain mutations of the TP53 gene, and that 9p loss and CDKN2A deletions are associated with progression from well-differentiated to anaplastic oligodendrogliomas. 10433931 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.080 Biomarker disease BEFREE Therefore, we have analyzed molecular genetic alterations involving chromosomes 1p, 10q, and 19q and the TP53 (on chromosome 17p) and CDKN2A (on chromosome 9p) genes, in addition to clinicopathologic features in 39 patients with anaplastic oligodendrogliomas for whom chemotherapeutic response and survival could be assessed. 9776413 1998