Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 Biomarker disease BEFREE CT scan of abdomen/pelvis showed obstructive mass which was found to be colon adenocarcinoma which on further molecular analysis tested positive for KRAS, NRAS and BRAF mutations. 31519714 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 Biomarker disease BEFREE Site-specific Differences in Colonic Adenocarcinoma: KRAS Mutations and High Tumor Budding Are More Frequent in Cecal Adenocarcinoma. 29240583 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 Biomarker disease BEFREE Patients ≥ 18 years old with histologically or cytologically confirmed adenocarcinoma of the colon or rectum and known KRAS status who were refractory or intolerant to two or more prior chemotherapy regimens were enrolled. 29215955 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE Words used in radiology reports, which have direct implications on disease course, tumor burden, and therapy, appear with differing frequency in patients with KRAS mutations versus wild-type colon adenocarcinoma. 28869500 2017
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE An ¹⁸F-FDG PET/CT in an asymptomatic 74-year-old woman with a thyroid cytology suggestive of malignancy but uncertain about the origin of the tumor revealed an stage IV colon adenocarcinoma with KRAS mutation and multiple metastasis (thyroid, lung, and liver). 28872477 2017
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE Correlate the expression of CD44 and CD166 markers in metastatic colon adenocarcinoma and KRAS mutation status (wild-type/mutated) with clinical pathological features and patients' outcome. 27062566 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE We examined the prognostic impact of specific KRAS mutations in patients with stage III colon adenocarcinoma receiving adjuvant FOLFOX alone or combined with cetuximab in a phase III trial (N0147). 24687927 2014
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE The prognostic value of KRAS mutations in colon adenocarcinoma is controversial. 25294886 2014
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 Biomarker disease BEFREE Using lung and colon adenocarcinoma cell lines, we assessed antiproliferative effects of KRAS silencing in vitro. 25281617 2014
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE Patients with mutant KRAS metastatic adenocarcinoma of the colon or rectum refractory to fluoropyrimidine- and oxaliplatin-based chemotherapy were randomized 1 : 1 : 1 to receive intravenous FOLFIRI plus conatumumab 10 mg/kg (Arm A), ganitumab 12 mg/kg (Arm B), or placebo (Arm C) Q2W. 23510984 2013
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE Role of oncogenic pathways and KRAS/BRAF mutations in the behavior of colon adenocarcinoma in renal transplant patients. 22245873 2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE We assessed DNA repair efficiency over time, in vitro, in human colon adenocarcinoma HT-29 (wild-type KRAS) and HCT-116 (mutated KRAS) cell lines treated with Dbait in combination with 5-fluorouracil and/or camptothecin. 22068457 2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE Colonic adenocarcinoma contained a KRAS mutation in 18 (33%) of 55 cases. 22804747 2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE Caco-2 human colon adenocarcinoma cells were stably transfected with BRAF(V600E) (Caco-BR cells) or KRAS(G12V) (Caco-K cells) oncogenes. 19881948 2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE K-RAS point mutation, and amplification of C-MYC and C-ERBB2 in colon adenocarcinoma. 15493579 2004
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE A novel activating mutation of the K-ras gene in human primary colon adenocarcinoma. 11095964 2000
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE The aim of the present study was to assess the cytotoxicity of manumycin, a specific inhibitor of farnesyl:protein transferase, as well as its effects on protein isoprenylation and kinase-dependent signal transduction in COLO320-DM human colon adenocarcinoma which harbours a wild-type K-ras gene. 10732765 2000