Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 400916
Gene Symbol: CHCHD10
CHCHD10
0.200 Biomarker disease HPO
Entrez Id: 400916
Gene Symbol: CHCHD10
CHCHD10
0.200 GeneticVariation disease BEFREE CHCHD10 is a homolog of CHCHD2; similar to CHCHD2, various mutations of CHCHD10 have been identified in a broad spectrum of neurological disorders, including FTD and AD, with a high frequency of CHCHD10 mutations found in motor neuron diseases. 31526091 2020
Entrez Id: 400916
Gene Symbol: CHCHD10
CHCHD10
0.200 Biomarker disease BEFREE A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement. 24934289 2014
Entrez Id: 400916
Gene Symbol: CHCHD10
CHCHD10
0.200 AlteredExpression disease BEFREE A significant decrease in CHCHD10 protein level was observed in ALS patient spinal cord and FTD patient frontal cortex. 31690696 2020
Entrez Id: 400916
Gene Symbol: CHCHD10
CHCHD10
0.200 GeneticVariation disease BEFREE Considering the clinical phenotype and pathology characterization were overlapped between FTD and Alzheimer disease (AD), and so far, no systematic analysis of CHCHD10 mutation was conducted in patients with AD in Asian population. 27578015 2017
Entrez Id: 400916
Gene Symbol: CHCHD10
CHCHD10
0.200 GeneticVariation disease BEFREE Dominant mutations in CHCHD10 cause amyotrophic lateral sclerosis (ALS)/frontotemporal dementia, and mutations in CHCHD2 have been associated with Parkinson's disease, but the function of these proteins remains unknown. 29121267 2018
Entrez Id: 400916
Gene Symbol: CHCHD10
CHCHD10
0.200 Biomarker disease BEFREE In addition, MAPT and CHCHD10 might be more important genes affecting Chinese with FTD. 28462717 2017
Entrez Id: 400916
Gene Symbol: CHCHD10
CHCHD10
0.200 GeneticVariation disease BEFREE Mutations in CHCHD10 have recently been described as a cause of frontotemporal dementia (FTD) comorbid with amyotrophic lateral sclerosis (ALS). 25726362 2015
Entrez Id: 400916
Gene Symbol: CHCHD10
CHCHD10
0.200 GeneticVariation disease BEFREE Mutations in CHCHD10 have recently been reported as a cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. 26344877 2015
Entrez Id: 400916
Gene Symbol: CHCHD10
CHCHD10
0.200 GeneticVariation disease BEFREE Mutations of CHCHD10 are associated with amyotrophic lateral sclerosis (ALS) and/or frontotemporal lobe dementia (FTD), motor neuron disease, and late-onset spinal muscular atrophy and autosomal dominant mitochondrial myopathy. 27631878 2017
Entrez Id: 400916
Gene Symbol: CHCHD10
CHCHD10
0.200 Biomarker disease BEFREE The present study confirms the role of CHCHD10 and TUBA4A in the FTD-ALS spectrum, although genetic variations in these 2 genes are extremely rare in the Belgian population and often associated with symptomatology of related neurodegenerative diseases including Parkinson's disease and Alzheimer's disease. 28069311 2017
Entrez Id: 400916
Gene Symbol: CHCHD10
CHCHD10
0.200 Biomarker disease BEFREE This study demonstrates the implication of CHCHD10 in FTD and ALS spectrum. 25155093 2014