Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Frontotemporal dementia-associated protein "phosphorylated TDP-43" localizes to atherosclerotic lesions of human carotid and main cerebral arteries. 31259382 2020
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Insoluble, hyperubiquitylated TAR DNA binding protein of 43 kDa (TDP-43) in the central nervous system characterizes frontotemporal dementia and ALS in many individuals with these neurodegenerative diseases. 31780563 2020
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 mice. 31690696 2020
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Together with our observation that ATG7 is reduced in ALS-FTD brain tissues, these findings identify the autophagy pathway as one key effector of nuclear depletion of TARDBP that contributes to neurodegeneration. 31242080 2020
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 GeneticVariation disease BEFREE Indeed, a growing number of FTD and/or ALS related RBPs coding genes (TDP43, FUS, EWSR1, TAF15, hnRNPA1, hnRNPA2B1, ATXN2, TIA1) have been identified to interfere with SG formation through mutation of their low-complexity domain (LCD), and thereby cause or influence disease. 31626953 2020
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Frontotemporal lobar degeneration with TDP-43 immunoreactive (TDP-ir) inclusions (FTLD-TDP) is sub-classified based on the pattern of neocortical pathology, with each subtype showing clinical and genetic correlations. 31501924 2020
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Prominent examples are amyloid beta and tau in Alzheimer's disease, α-synuclein in Parkinson's disease and transactive response DNA binding protein 43 kDa (TDP-43) in ALS and FTD. 31132469 2020
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 GeneticVariation disease BEFREE Here we provide a statistically rigorous method to account for staining batch effects in a large sample of brain tissue with frontotemporal lobar degeneration with tau inclusions (FTLD-Tau, <i>N</i> = 39) or TDP-43 inclusions (FTLD-TDP, <i>N</i> = 53). 31333403 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 GeneticVariation disease BEFREE Different morphological characteristics of TDP-43 immunoreactive inclusions define the different variants of FTLD-TDP. 31266542 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Thus, premature polyadenylation-mediated reduction in stathmin-2 is a hallmark of ALS-FTD that functionally links reduced nuclear TDP-43 function to enhanced neuronal vulnerability. 30643298 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Aggregates of the RNA-binding protein TDP-43 (TAR DNA-binding protein) are a hallmark of the overlapping neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. 30824544 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Cytoplasmic aggregates and nuclear depletion of the ubiquitous RNA-binding protein TDP-43 have been described in the autoptic brain tissues of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTLD) patients and both TDP-43 loss-of-function and gain-of-function mechanisms seem to contribute to the neurodegenerative process. 31766750 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE TDP-43 (transactive- response DNA binding protein) amazes structural biologist as its aberrant ubiquitinated cytosolic inclusions is largely involved in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 30315897 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE We developed transgenic mice conditionally overexpressing human wild-type TDP-43 protein (hTDP-43-WT) in forebrain neurons, a model that recapitulates several key features of FTD. 31068973 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Here we demonstrate that another hnRNP family member, hnRNP E2, shows a striking accumulation within dystrophic neurites and cytoplasmic inclusions in the frontal cortex and hippocampus of a subset of FTLD-TDP cases belonging to pathological subtypes A and C, where hnRNP E2 was found to co-localize with 87% of TDP-43 immunopositive inclusions. hnRNP E2-positive inclusions were not seen in FTLD-TDP cases with the <i>C9orf72</i> expansion or in any other neurodegenerative disorders examined. 31213972 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Defects in nucleocytoplasmic transport in FTD point to important commonalities in the pathogenic mechanisms of tau-mediated dementias and ALS-FTD due to TDP-43 and C9orf72 mutations. 30650353 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Pathological aggregation of the transactive response DNA-binding protein of 43 kDa (TDP-43) is associated with several neurodegenerative disorders, including ALS, frontotemporal dementia, chronic traumatic encephalopathy, and Alzheimer's disease. 30814253 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Here we constructed a conditional TDP-43 mouse with depletion of TDP-43 in the mouse forebrain and find that the mice exhibit a whole spectrum of age-dependent frontotemporal dementia-like behaviour abnormalities including perturbation of social behaviour, development of dementia-like behaviour, changes of activities of daily living, and memory loss at a later stage of life. 30922385 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE The RNA-binding protein TDP-43, associated to amyotrophic lateral sclerosis and frontotemporal dementia, regulates the alternative splicing of several genes, including the skipping of TNIK exon 15. 31382054 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Recently, we further showed that these specialized neurons show preferential aggregation of TDP-43 in FTLD-TDP. 31640778 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE These studies demonstrate the significance of the salt bridge in sustaining TDP43 stability and RNA binding properties, factors that are crucial for neurodegeneration arising from TDP43 deposition in ALS and FTD. 31018129 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Frontotemporal dementia is a group of early onset dementia syndromes linked to underlying frontotemporal lobar degeneration (FTLD) pathology that can be classified based on the formation of abnormal protein aggregates involving tau and two RNA binding proteins, TDP-43 and FUS. 30355151 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 GeneticVariation disease BEFREE In amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), pathology is often associated with aggregation of TAR DNA-binding protein 43 (TDP-43). 31495585 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Numerous patient mutations in TARDBP, the gene encoding TDP-43, combined with data from animal and cell-based models, imply that altered RNA regulation by TDP-43 causes Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. 30357366 2019
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.700 Biomarker disease BEFREE Phase-separated compartments can concentrate specific RNA-binding proteins (RBPs), such as TDP-43 and fused in sarcoma (FUS), that through low-complexity, prion-like domains have an intrinsic tendency to form self-templating fibrils that are closely tied to fatal neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. 30948513 2019