Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 Biomarker disease HPO
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE Frontotemporal Dementia and Chorea Associated with a Compound Heterozygous TREM2 Mutation. 29578490 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE TREM2 variants have also been shown to cause polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy and frontotemporal dementia. 30033062 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE TREM2 (triggering receptor expressed on myeloid cells 2) gene variants were reported to increase the risk of Alzheimer's disease (AD) and even other neurodegenerative diseases (frontotemporal dementia (FTD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS)), but so far, no definite conclusion has been drawn. 30883352 2019
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 Biomarker disease BEFREE A decrease in soluble TREM2 was also observed in the CSF of patients with AD and FTD, further suggesting that reduced TREM2 function may contribute to increased risk for two neurodegenerative disorders. 24990881 2014
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia. 24041969 2014
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE Biallelic loss-of-function mutations in TYROBP and TREM2 cause a rare disease that resembles early-onset frontotemporal dementia with bone lesions called polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). 29336840 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 AlteredExpression disease BEFREE Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup. 30111356 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE Given recent findings of enrichment of rare TREM2 variants (including R47C) in Alzheimer's disease, it is notable that we detected a homozygous TREM2 R47C carrier presenting with an FTD rather than an Alzheimer's disease phenotype. 29748150 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE Here, we further confirm the association of TREM2 mutations with FTD-like phenotypes by reporting the first compound heterozygous mutation in a Turkish family. 23870839 2013
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE Homozygous TREM2 mutation in a family with atypical frontotemporal dementia. 24910390 2014
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE Homozygous TREM2 missense mutations, such as p.T66M, lead to the FTD-like syndrome, but how they cause pathology is unknown. 28559417 2017
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE Our data corroborate and extend previous findings to include an increased frequency of rare heterozygous TREM2 variations in AD and FTD, and show that TREM2 variants may play a role in neurodegenerative diseases in general. 24119542 2014
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE Our results suggest that the TREM2 p.R47H substitution is a risk factor for frontotemporal dementia and Parkinson's disease in addition to Alzheimer's disease. 23800361 2013
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 Biomarker disease GENOMICS_ENGLAND Parkinsonism, movement disorders and genetics in frontotemporal dementia. 26891767 2016
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE Recently, variants in TREM2 were also associated with frontotemporal dementia and Alzheimer's disease. 28716534 2017
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE Several heterozygous missense mutations in the triggering receptor expressed on myeloid cells 2 (TREM2) have recently been linked to risk for a number of neurological disorders including Alzheimer disease (AD), Parkinson disease, and frontotemporal dementia. 26374899 2015
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 Biomarker disease BEFREE Soluble TREM2 was elevated in both dementia groups but did not show any difference between AD and FTD. 30292090 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE The FTD and AD groups were not significantly different with regard to TREM2 genetic variation frequency (AD: 2.6%, p = 0.39). 24139279 2014
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 Biomarker disease BEFREE The entire coding sequence of TREM2 was sequenced in FTD-S patients of Spanish (n = 539) and German (n = 63) origin. 25042114 2014
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE The previously reported functional mutation rs75932628-T (p.R47H) in the triggering receptor expressed on myeloid cells 2 (TREM2) is a genetic risk factor for Alzheimer's disease, Parkinson's disease (PD) and frontotemporal dementia, in European populations. 26758262 2016
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement. 23318515 2013
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE We conclude that TREM2 mutations are extremely rare in patients with pure FTD, although further investigation in larger populations is needed. 23759145 2013
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.500 GeneticVariation disease BEFREE We confirm previous data that homozygous and compound heterozygous TREM2 mutations can be causative for FTD. 29557178 2018