Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE Insoluble, hyperubiquitylated TAR DNA binding protein of 43 kDa (TDP-43) in the central nervous system characterizes frontotemporal dementia and ALS in many individuals with these neurodegenerative diseases. 31780563 2020
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 GeneticVariation disease BEFREE <b>Background:</b> Pathogenic variants in ALS genes are known to be present in up to 70% of familial and 10% of apparently sporadic ALS cases, and can be associated with risks for ALS only, or risks for other neurodegenerative diseases (eg. frontotemporal dementia). 31702461 2019
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE All five compounds also inhibited RAN translation of expanded GGGGCC repeats associated with ALS and FTD. 31649034 2019
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 GeneticVariation disease BEFREE Genotype/phenotype correlation reveals clinical pleiotropy for several ALS genes, which can be linked, for example, to ataxia or Parkinsonian syndromes beyond classical ALS and frontotemporal dementia (FTD) phenotypes. 31335339 2019
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 GeneticVariation disease BEFREE Pathogenic mutations in known frontotemporal dementia (FTD)/ALS genes were identified in 100% of these familial PPA cases but only 50% of familial PPA-ALS cases, suggesting the involvement of novel genetic variants in this underacknowledged phenotype. 30770429 2019
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features. 30454072 2018
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE Collectively, our evidence demonstrates that human ALS/FTD-linked mutations in FUS induce a gain of toxicity that includes stress-mediated suppression in intra-axonal translation, synaptic dysfunction, and progressive age-dependent motor and cognitive disease without cytoplasmic aggregation, altered nuclear localization, or aberrant splicing of FUS-bound pre-mRNAs.VIDEO ABSTRACT. 30344044 2018
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE Most of reports describing ASL-FTD cases show a strong association between ALS and the behavioural form of FTD. 30146930 2019
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE No mutation in the LCD of TIA1 was found in the familial ALS and FTD patients. 29773329 2018
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE The comprehensive characterisation of striatal and thalamic pathology along the ALS-FTD spectrum is particularly timely, as dysfunction of frontostriatal and cortico-thalamic networks contribute to phenotype-defining cognitive, behavioral, and motor deficits. 29423814 2018
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE hnRNPA2, a component of RNA-processing membraneless organelles, forms inclusions when mutated in a syndrome characterized by the degeneration of neurons (bearing features of amyotrophic lateral sclerosis [ALS] and frontotemporal dementia), muscle, and bone. 29358076 2018
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE In the first stage, 12 studies involving 4173 ALS/FTD patients were included. 29349657 2018
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE Modules were also examined for their overlap with TDP-43 protein-protein interactions, revealing one module enriched with RNA-binding proteins and other causal ALS genes that increased in FTD/ALS and FTD cases. 29191947 2018
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 GeneticVariation disease BEFREE Previous studies indicate that causative mutations in AD and FTD/ALS genes can be found in clinical familial AD. 29091718 2017
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE Cluster analysis revealed significant class separation of FTD-ALS from controls. 28827549 2017
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE Neuronal inclusions of aggregated RNA-binding protein fused in sarcoma (FUS) are hallmarks of ALS and frontotemporal dementia subtypes. 28790177 2017
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE These findings suggest that PLS is part of the FTD-MND continuum and would favour viewing it as a subtype of ALS. 28745069 2017
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE This review summarizes the key points leading up to our current understanding of the genetic, clinical and neuropathological overlap between FTD and ALS. 28449882 2017
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE Together, these findings from ALS genetics provide new insight into therapies that target genetically distinct subsets of ALS and FTD. 28270533 2018
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE We investigated the primary motor cortices isolated from post-mortem normal control subjects, patients with familial ALS (fALS), sporadic ALS (sALS), ALS with frontotemporal dementia (FTD-ALS), and Alzheimer's disease (AD), and found profound apical dendrite degeneration of Betz cells in both fALS and sALS, as well as FTD-ALS patients. 28165465 2017
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 GeneticVariation disease BEFREE Fifty-seven percent consider a family history of frontotemporal dementia and 48.5% the presence of a known ALS genetic mutation as sufficient for a diagnosis of FALS. 28159885 2017
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE Investigating the role of ALS genes CHCHD10 and TUBA4A in Belgian FTD-ALS spectrum patients. 28069311 2017
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 Biomarker disease BEFREE Bidirectional Transcriptional Inhibition as Therapy for ALS/FTD Caused by Repeat Expansion in C9orf72. 28009271 2016
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 GeneticVariation disease BEFREE Behavioral changes were defined as >22 points on the ALS-Frontotemporal-Dementia-Questionnaire or ≥3 points on ≥2 items of the Neuropsychiatric Inventory. 27671483 2016
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.100 GeneticVariation disease BEFREE An expanded hexanucleotide repeat in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal dementia (c9FTD/ALS). 27516603 2016