Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 Biomarker disease BEFREE This cell model can be valuable for the study of the role of PGRN in the pathogenesis in FTLD-TDP. 31626287 2019
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE The objective of this work was to elucidate the association between PGRN deficiency, WNT5A signalling and cell proliferation in immortalized lymphoblasts from carriers of the c.709-1G > A GRN mutation (asymptomatic and FTLD-TDP). 26624524 2016
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 Biomarker disease BEFREE Our results indicate that central nervous progranulin reduction is not restricted to the relatively rare cases of FTD caused by GRN LoF mutations, but also contributes to the more common GRN-negative forms of FTD. 27760429 2017
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE Clinical, neuropathological, and genetic characteristics of the novel IVS9+1delG GRN mutation in a patient with frontotemporal dementia. 22366770 2012
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE We hypothesized a higher risk for the latter with immanent neurologic diseases and studied this potential interrelationship in progranulin-deficient mice, which are a model for frontotemporal dementia, a disease dominated by behavioral abnormalities in humans. 28720486 2017
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE Measurable cognitive differences exist before the development of frontotemporal dementia in subjects with GRN mutations. 24993774 2014
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE The clinical and neuropathologic features of frontotemporal dementia with parkinsonism linked to chromosome 17 and the nature of the mutations in the progranulin and microtubule-associated protein tau genes are emphasized. 17659186 2007
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE Loss of function mutations in progranulin cause tau-negative frontotemporal lobar degeneration with ubiquitin-positive inclusions. 17984093 2008
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE To this end, we differentiated 9 induced pluripotent stem cell lines derived from a control subject, a sporadic FTD case and an FTD patient with progranulin S116X mutation. 27143419 2016
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 Biomarker disease BEFREE FTD associated with parkinsonism occurs frequently as a result of mutations in the C9orf72 gene and also in the genes coding for the protein associated with microtubule tau (MAPT) and progranulin (GRN) on chromosome 17 (FTDP-17). 28268100 2017
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE A third PGRN sequence variation (R433W) was found in an FTD patient with family history of ALS. 17202431 2007
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE We investigated whether progranulin plasma levels are predictors of the presence of progranulin gene (GRN) null mutations or of the development of symptoms in asymptomatic at risk members participating in the Genetic Frontotemporal Dementia Initiative, including 19 patients, 64 asymptomatic carriers, and 77 noncarriers. 29146050 2018
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE Results revealed: 1) prevalence is approximately 10%, 2) TDP-43 type B and FUS pathologies might have relatively high frequency of psychosis, 3) psychosis in FTD is higher with genetic mutations of C9ORF72 and GRN, 4) imaging researches did not achieve conclusive results, and 5) no treatment for psychosis in FTD is currently available. 24898651 2014
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE The data suggest degeneration of the cortico-cortical and cortico-hippocampal pathways in FTLD-TDP with GRN mutation, the NCI and NII affecting different clusters of neurons. 21154232 2011
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE Eligible participants (aged ≥18 years) either had frontotemporal dementia due to a pathogenic mutation in GRN, C9orf72, or MAPT (symptomatic mutation carriers) or were healthy at-risk first-degree relatives (either presymptomatic mutation carriers or non-carriers), and had at least two serum samples with a time interval of 6 months or more. 31701893 2019
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 AlteredExpression disease BEFREE We characterized mRNA and protein levels of progranulin from four brain regions (frontal cortex, temporal cortex, occipital cortex, and cerebellum) in FTLD-TDP patients with and without GRN mutations, as well as neurologically normal individuals. 19649643 2010
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE No study but one has suggested the presence of white matter hyperintensities (WMHs) in frontotemporal dementia (FTD), limited to 4 cases carrying pathogenic Granulin (GRN) gene mutations. 26827655 2016
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE Null mutations in progranulin gene (GRN) are one of the most frequent genetic determinants in familial frontotemporal dementia. 29226876 2018
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 Biomarker disease BEFREE Progranulin is implicated in frontotemporal dementia (FTD), but its role in other neurodegenerative disorders is unknown. 26682689 2016
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE Parkinsonism in frontotemporal dementia (FTD) was first described in families with mutations in the microtubule-associated protein tau (MAPT) and progranulin (PRGN) genes. 24998994 2014
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE We performed <sup>18</sup>F-flortaucipir imaging in patients with the FTD syndromes (n = 45): nonfluent variant primary progressive aphasia (nfvPPA) (n = 11), corticobasal syndrome (CBS) (n = 10), behavioral variant frontotemporal dementia (bvFTD) (n = 10), semantic variant primary progressive aphasia (svPPA) (n = 2) and FTD associated pathogenic genetic mutations microtubule-associated protein tau (MAPT) (n = 6), chromosome 9 open reading frame 72 (C9ORF72) (n = 5), and progranulin (GRN) (n = 1). 30704514 2019
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 Biomarker disease BEFREE Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. 29511098 2018
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE The clinical phenotype of frontotemporal dementia patients carrying progranulin (GRN) mutations is known to be heterogeneous. 23813535 2013
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE We therefore investigated 33 patients with FTLD-tau (including 9 with MAPT mutation) for TDP-43 pathological changes, and 45 patients with FTLD-TDP (including 12 with hexanucleotide expansion in C9ORF72 and 12 with GRN mutation), and 23 patients with motor neurone disease (3 with hexanucleotide expansion in C9ORF72), for tauopathy. 24861427 2014
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.900 GeneticVariation disease BEFREE In recent years, molecular genetic findings in these syndromes, especially the tau and progranulin mutations on chromosome 17, have provided a molecular and genetic foundation for the understanding of frontotemporal dementia. 20717853 2010