Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
0.100 Biomarker disease BEFREE Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study. 31701893 2019
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
0.100 Biomarker disease BEFREE Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia. 30953863 2019
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
0.100 Biomarker disease BEFREE Levels of CSF NFL are associated with cognitive impairments in patients with Alzheimer disease and frontotemporal dementia. 30508027 2019
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
0.100 Biomarker disease BEFREE The single biomarkers or biomarker combinations generating the best area under the receiver operating characteristics (AUROCs) were the following: the combination [amyloid β peptide + phosphorylated tau + neurofilament light chain] for distinguishing between ADD patients and HC (AUROC = 0.86), t-tau for distinguishing between ADD and FTD patients (AUROC = 0.82), and t-tau for distinguishing between FTD patients and HC (AUROC = 0.78). 29328927 2018
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
0.100 AlteredExpression disease BEFREE Cerebrospinal fluid NFL levels were quantified in nonprimarily neurodegenerative neurological and psychiatric diseases (n = 122), mild cognitive impairment (n = 48), Alzheimer's disease (n = 108), dementia with Lewy bodies/Parkinson's disease dementia (n = 53), vascular dementia (n = 46), frontotemporal dementia (n = 41), sporadic Creutzfeldt-Jakob disease (sCJD, n = 132), and genetic prion diseases (n = 182). 29391125 2018
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
0.100 Biomarker disease BEFREE To examine the clinical value of neurofilament light chain (NfL) and the phospho-tau/total tau ratio (p/t-tau) across the entire frontotemporal dementia (FTD) spectrum in a large, well-defined cohort. 29514947 2018
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
0.100 Biomarker disease BEFREE We analyzed 3 CSF biomarkers: the soluble β-fragment of amyloid precursor protein (sAPPβ), YKL-40, and neurofilament light (NfL) in FTD (n = 86), ALS (n = 38), and a group of age-matched cognitively normal controls (n = 49). 30291183 2018
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
0.100 Biomarker disease BEFREE To evaluate poly(GP), a dipeptide repeat protein, and neurofilament light chain (NfL) as biomarkers in presymptomatic <i>C9orf72</i> repeat expansion carriers and patients with <i>C9orf72-</i>associated frontotemporal dementia. 29761121 2018
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
0.100 Biomarker disease BEFREE Cerebrospinal fluid (CSF) neurofilament light chain protein (NfL) and Alzheimer's disease (AD) core biomarker levels have been evaluated in cohorts of patients with frontotemporal dementia spectrum (FTD), but the distribution of values across the different clinical syndromes and underlying proteinopathies, and the relative diagnostic accuracy appear discordant among studies. 30320576 2018
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
0.100 Biomarker disease BEFREE In sum, CSF-Neurofilament light chain and CSF-Progranulin seem to be promising biomarkers for FTD, the latter predominantly for assumed TDP43-mediated FTD. 30013506 2018
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
0.100 Biomarker disease BEFREE Higher concentrations of CSF NFL were associated with shorter survival in both MND and FTD. 28631955 2017
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
0.100 AlteredExpression disease BEFREE The levels of CSF NF-L detected in p25 mice are about 4-fold higher than the CSF levels detected in patients with chronic neurodegenerative diseases, such as symptomatic FTD (bvFTD). 28392472 2017
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
0.100 Biomarker disease BEFREE We assessed the diagnostic accuracy of cerebrospinal fluid (CSF) neurofilament light chain (NFL) protein in the classification of patients with Alzheimer's disease (AD) and cognitively healthy control individuals (HCs) and patients with frontotemporal dementia (FTD) as comparisons. 28527630 2017
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
0.100 Biomarker disease BEFREE Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia. 27581216 2016