Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 AlteredExpression disease BEFREE Overall, this study suggests that PK exhibits a neuroprotective effect by inducing alternative activation of microglia and downregulating the BACE1 expression, thereby ameliorating the disease pathophysiology and reversing the cognitive decline related to Aβ deposition in AD mice. 31741224 2020
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE Previous studies indicated that BACE1 initially cleaves the amyloid precursor protein (APP) and may subsequently interfere with physiological functions of proteins such as PKA, which is recognized to be closely associated with long-term potentiation (LTP) level and can effectively ameliorate cognitive impairments. 31223308 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE Using this system to target Bace1 suppressed amyloid beta (Aβ)-associated pathologies and cognitive deficits in two mouse models of Alzheimer's disease. 30858603 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE It has been hypothesised that partial inhibition of BACE1 in individuals with a high risk of developing Alzheimer's disease may be beneficial in preventing cognitive decline. 31547430 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation. 30596903 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 AlteredExpression disease BEFREE Depletion of NRF2 increases <i>BACE1</i> and <i>BACE1-AS</i> expression and Aβ production and worsens cognitive deficits. 31164420 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE We found miR-361-3p inhibited β-amyloid accumulation by targeting BACE1, which thus weakened cognitive deficits in Alzheimer's disease. 31601077 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 AlteredExpression disease BEFREE Hypomethylation of these enhancers in AD is associated with an upregulation of BACE1 transcripts and an increase in amyloid plaques, neurofibrillary tangles, and cognitive decline. 31113950 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 AlteredExpression disease BEFREE Surprisingly, blocking GRs for only 3 days at 12 months of age reduced CORT levels, reduced hippocampal Aβ40 and -42, and β-site APP-cleaving enzyme 1 (BACE1) levels, and notably rescued the cognitive deficits in 12-month-old APPswe/PS1dE9 mice. 29491368 2018
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 AlteredExpression disease BEFREE Ng/BACE1 levels were elevated in both subjective cognitive decline and mild cognitive impairment compared to healthy controls. 30519627 2018
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE The senile plaques (SPs) in the brain are one of the most pathophysiological characteristics of cognitive dysfunction and its major constituent amyloid β (Aβ) released from amyloid precursor protein (APP) by β (BACE1) and γ (presenilin 1) secretases . 29775888 2018
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE However, so far pharmacological BACE1 inhibition failed to rescue the cognitive decline in mild-to-moderate AD patients, which indicates that treatment at the symptomatic stage might be too late. 29327084 2018
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE Chronic Sleep Restriction Induces Cognitive Deficits and Cortical Beta-Amyloid Deposition in Mice via BACE1-Antisense Activation. 28145081 2017
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE Finally, the lack of BACE1 S-palmitoylation mitigates cognitive deficits in 5XFAD mice. 29078331 2017
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease RGD Sleep deprivation accelerates the progression of alzheimer's disease by influencing Aβ-related metabolism. 28455102 2017
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE These data highlight the potential benefits of BACE inhibition for the effective treatment of a wide range of AD-like pathophysiological and cognitive impairments. 28739891 2017
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE These results indicate that DISC1 attenuates Aβ generation and cognitive deficits of APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1. 26062786 2016
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice. 25926467 2015
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 AlteredExpression disease BEFREE It suggests that BACE1 overexpression-induced SET upregulation may contribute to growth delay and cognitive impairment in DS patients. 24935721 2015
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE Previous studies have demonstrated that chronic brain hypoperfusion (CBH) causes Aβ aggregation by upregulating expression of amyloid precursor protein (APP) and β-site APP cleaving enzyme 1 (BACE1) protein, which is accompanied by cognitive impairment, but the mechanisms are not fully understood. 23447608 2013
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 AlteredExpression disease BEFREE Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments. 22275252 2012
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment. 20505099 2010
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE We demonstrate that genetic reductions of both BACE1 and gamma-secretase additively attenuate the amyloid burden and ameliorate cognitive deficits occurring in aged APPswe/PS1DeltaE9 animals. 20371462 2010
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 Biomarker disease BEFREE In this study, we used heterozygous BACE1 gene knockout (BACE1+/-) mice to evaluate the effects of partial BACE1 suppression on different types of synaptic and cognitive dysfunctions in Alzheimer's transgenic mice (5XFAD model). 20089133 2010
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.300 AlteredExpression disease BEFREE We have recently shown that Alzheimer's disease (AD) transgenic mice given a moderate level of caffeine intake (the human equivalent of 5 cups of coffee per day) are protected from development of otherwise certain cognitive impairment and have decreased hippocampal amyloid-beta (Abeta) levels due to suppression of both beta-secretase (BACE1) and presenilin 1 (PS1)/gamma-secretase expression. 19581722 2009