Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE The effect of histone deacetylase (HDAC)2/Inositol polyphosphate-5-phosphatase F (Inpp5f) on neuropathic pain and cognitive dysfunction through regulating PI3K/Akt/GSK-3β signal pathway in rats with neuropathic pain was investigated. 31281447 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE These findings indicate that the blockade of Kv channels by TEA and 4-AP ameliorates the diabetes-associated cognitive dysfunction via PI3K/Akt pathway, suggesting that targeting Kv channels could be a promising strategy for the treatments of cognitive impairments in diabetes. 31254519 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Exendin-4 attenuates brain mitochondrial toxicity through PI3K/Akt-dependent pathway in amyloid beta (1-42)-induced cognitive deficit rats. 31004737 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE In conclusion, the results of our study confirmed lncRNA LOC103690121 promoted STZ-induced cognitive impairment in diabetic rats by promoting neuron apoptosis through PI3K/Akt signaling pathway. 30851305 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE The aim of the current experimental study was to scrutinize the neuroprotective effect of ketamine on the isoflurane (iso)-induced cognitive dysfunction in rats via phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase 3β (GSK-3β) pathway. 30787593 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE This current study suggests that upregulation of miR-196a and downregulation of LRIG3 improve cognitive impairment and alleviate neuronal damage in hippocampus tissues in AD rats via the modulation of the PI3K/Akt pathway. 31119777 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 AlteredExpression disease BEFREE In conclusion, dimenazine-induced stimulation of ACE2/Ang(1-7)/Mas axis subdues cognitive deficits in AD most probably through activation of PI3K/Akt pathway. 29516284 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Overall, these findings will help elucidate how the PI3K/Akt/mTOR pathway intersects with Wnt signaling to result in cognitive impairments, specifically in memory. 30086265 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Liraglutide improves cognitive impairment via the AMPK and PI3K/Akt signaling pathways in type 2 diabetic rats. 29916537 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE These results indicate that PER attenuates infarct volumes and motor function deficits possibly through its anti-inflammatory, antioxidant, and anti-apoptotic activities, mediated via activation of phosphatidylinositol 3-kinase (PI3K)/Akt pathways in the acute ischemic phase, and further ameliorates post-stroke cognitive impairments via the suppression of secondary neuronal damage in the chronic ischemic phase. 29981363 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 AlteredExpression disease BEFREE VEGF attenuates 2-VO induced cognitive impairment and neuronal injury associated with the activation of PI3K/Akt and Notch1 pathway. 29248560 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE The results provide evidence that curcumin exercises its neuroprotective effect involving PI3K/Akt pathway which may affect NMDA receptors and downstream signalling through TrKβ and BDNF in arsenic induced cognitive deficits in hippocampus. 29723552 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Berberine exerts the protective effect against cognitive deficits by improving tau hyperphosphorylation and the axonal damage through restoring PI3K/Akt/GSK3β signaling pathway. 30175975 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE These studies demonstrate that EPO is an effective neuroprotective agent in the context of diabetes-associated cognitive dysfunction and show that this effect involves the PI3K/Akt/GSK-3β pathway. 28584284 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Autophagy and phosphatidylinositol 3-kinase (PI3K)/Akt kinase pathways are implicated in cognitive decline associated with cerebrovascular lesions. 28782464 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Histone deacetylase-2 is involved in stress-induced cognitive impairment via histone deacetylation and PI3K/AKT signaling pathway modification. 28656275 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Zeaxanthin improves diabetes-induced cognitive deficit in rats through activiting PI3K/AKT signaling pathway. 28599877 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Puerarin attenuates locomotor and cognitive deficits as well as hippocampal neuronal injury through the PI3K/Akt1/GSK-3β signaling pathway in an <i>in vivo</i> model of cerebral ischemia. 29290948 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Cognitive Dysfunctions in Intellectual Disabilities: The Contributions of the Ras-MAPK and PI3K-AKT-mTOR Pathways. 28859574 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE The inhibition of the PI3K/Akt pathway significantly suppressed GJIC and cognitive impairment. 29312496 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Neuroprotective effect of miR-665 against sevoflurane anesthesia-induced cognitive dysfunction in rats through PI3K/Akt signaling pathway by targeting insulin-like growth factor 2. 28386360 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Collectively, the results showed that TBN alleviated white matter lesion and impairment of cortex and hippocampus, attenuated oxidative damage and enhanced axonal outgrowth through the regulation of PI3K/Akt/GSK3β signaling pathway, leading to improved cognitive deficit in a rat chronic hypoperfusion model. 28342896 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE It is thought that reduced activity of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway could at least partially explain the cognitive impairment, synaptic morphologic abnormality, neuronal atrophy and dysfunction of neurotransmitter signaling in schizophrenia. 22771711 2012
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease HPO